Science

…alcohol study… published in the Lancet… finds only risks, zero benefits for young adults

The analysis published in The Lancet Medical Journal suggests that for young adults ages 15-39, there are no health benefits to drinking alcohol, only health risks. “Our message is simple: young people should not drink, but older people [ages 40+ without underlying health conditions] may benefit from drinking small amounts… it’s important to communicate the…

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Restrictions on psilocybin ‘magic mushrooms’ are easing as research ramps up

Following the 1971 United Nations Convention on Psychotropic Substances, psilocybin was classed in the U.S. as a Schedule I substance—defined as having “no currently accepted medical use and a high potential for abuse.” Psilocybin production was limited, and a host of administrative and financial burdens effectively ended study for decades. “It’s the worst censorship of…

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Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls

To our knowledge, this is the largest longitudinal study to date of microdosing psilocybin and one of the few studies to engage a control group. In light of these methodological strengths, the comparability of our findings with those of prior research from diverse locations and with different methodologies suggests a relatively consistent association between microdosing…

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[Beer… coffee… fentanyl…]

….beer twice as expensive… That’s because the cost of a key ingredient, malted barley, could soar as…barley becomes harder to grow. The price of a six-pack in the United States might rise by as much as $8 on average, the study found… [coffee] six-in-ten of the known species of coffee are now under threat of…

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Anti-inflammatory effects of four psilocybin-containing magic mushroom [psilocybe & panaeolus] water extracts 

Mushrooms were grown and extracted with boiling hot water. Effects of the four water extracts on 15-LOX activity were determined… natural [fungi] with medicinal properties have been used to treat all sorts of inflammatory conditions and studies have shown that natural products have advantageous structural diversity over synthetic compounds, which thus make them a potential…

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Comparing… mushrooms and truffles…

…psilocybin truffles have “a lot of psilocybin but little psilocin.” This hypothesis is corroborated in the literature. …, Pellegrini et al. reported: “…no trace of psilocin could be found at least at the limit of the detection of the assay” (0.3 µg per 100 mg truffles). In stark contrast, a 2019 study… found that a…

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…to define…

So what has science been able to offer since Shulgin? There have been at least two contributions to the field: The first is the structural determination of a psychedelic-bound 5-HT2A receptor at near-atomic resolution. These reconstructions have enabled detailed computer simulations to identify thousands of candidate compounds which can be tested to evaluate their kinetic…

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Myriad new drugs…

…by definition, the compounds are new and poorly understood… most people who use drugs wouldn’t want to use most NPS anyway, if better-known and better-studied equivalents were legally and widely accessible. An effort out of the University of Copenhagen called HighResNPS collects mass spectrometry data on novel psychoactive substances (NPS) from around the world. Its list, which…

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…magic mushroom… smell loss?

Later that night, he reveled in the enchiladas they had for dinner. “I could taste the individual ingredients,” he said. “I mean, it’s not anything I’d wish on anybody to lose their sense of smell, but to lose it and have it come back that abruptly was really — it was a special experience.” Neuroscientist…

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