Science

…in which a novel topological data analysis (TDA) method is applied to the neurophysiological study of the synergistic effects of meditation and psychedelics. …intriguing evidence of similarities in the phenomenology and neurophysiology of meditation and psychedelics has been found… recent reviews suggest that meditation and psychedelics exhibit similarities and complementary differences, which may indicate potential…

What are the notable acute adverse effects for therapeutic doses of psilocybin in the treatment of depression and anxiety? [Date Sources:] MEDLINE via PubMed, Web of Science, and ClinicalTrials.gov were searched for publications available between 1966 and November 30, 2023. In this meta-analysis of 6 randomized, double-blind clinical trials with 528 patients, headaches, nausea, anxiety,…

Psilocybin is formed by fungi in complex biochemical processes from the amino acid L-tryptophan. The enzyme PsiM, a methyltransferase, plays an important role in this process. It catalyzes two methylation reactions in succession, the last two steps in the production of psilocybin. …a team from the Medical University of Innsbruck led by crystallographer Bernhard Rupp and the…

The culture surrounding psychedelic drugs has shifted significantly over the past few years, with voters in Colorado leading that charge… I was speaking from a place of deep love for the psychedelics field, and a conviction that we need to talk more about how the corporadelic empire has no clothes. In 2019, Denver became the first U.S.…

Scientific research has shown that there is a link between inflammatory processes in the body and depression. Several inflammatory markers have been linked to depression, including TNF-alpha, IL-6 and CRP. These are exactly the inflammatory markers that psilocybin has a good influence on.  CRP, or C-reactive protein, is a natural inflammatory marker that increases in…

…mushroom extract demonstrated a stronger and more prolonged impact on synaptic plasticity… Metabolomic analyses indicated distinct metabolic profiles between the mushroom extract and synthetic psilocybin… Original Article (Neuroscience News & Nature):Mushroom extract outperforms synthetic psilocybin in psychiatric therapy & Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse…