Science

Magic mushrooms study suggest psilocybin may reverse alcohol-induced brain damage

The consumption of alcoholic beverages is responsible for 5.3 percent of deaths worldwide every year… in both groups of mice that received psilocybin, mGluR2 expression was restored following the treatment. This change was evident in the mice’s behavior, too: The psilocybin group relapsed roughly 45 percent less compared to the control mice. As hypothesized, mGluR2 expression was reduced in the brains…

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Psychedelic psilocybin cuts cravings and boosts key brain functions in rat models of alcohol use disorder

…set out to see whether psilocybin could restore the receptor’s expression and tamp down the desire to seek out alcohol while also restoring flexibility in cognition. The researchers gave the rats one of two different doses of psilocybin to see whether the magic mushroom ingredient was effective at reducing relapses. They found that both doses…

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Safe consumption sites are opening in New York city

…people will be able to obtain sterile syringes and other safer-use supplies, access treatment options and other services, and bring their own drugs to use, with trained staff and naloxone on hand. “This is a watershed milestone in the fight to end overdose deaths in New York,” Melissa Moore, the director of civil systems reform…

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New study suggests SSRI drugs can be used safely with psilocybin to treat depression

For the study, participants either received 10mg of escitalopram daily for seven days followed by 20mg daily for the next seven days, including the day of psilocybin administration, or 14 days of placebo pre-treatment before psilocybin administration.  The researchers found that pre-treatment with escitalopram did not alter the pharmacokinetics of psilocin — the active compound that the…

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The most common pain relief drug in the world induces risky behavior, study finds

Despite the seriousness of those findings, acetaminophen nonetheless remains one of the most used medications in the world, considered an essential medicine by the World Health Organization, and recommended by the CDC for pain relief at home… the findings are reported in Social Cognitive and Affective Neuroscience. “Acetaminophen seems to make people feel less negative emotion when they…

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Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs…

Among 3813 PWUD at baseline, 1093 (29%) reported daily use of illicit opioids and 229 (6%) reported psychedelic use in the past six months. Over study follow-up after adjusting for a range of potential confounders, psychedelic use remained independently associated with a significantly reduced odds of subsequent daily opioid use (Adjusted Odds Ratio: 0.45; 95%…

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Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers

This examination of a large international sample of adults highlights the prominence of therapeutic and wellness motivations for microdosing psychedelic drugs and identified lower levels of anxiety and depression among microdosers relative to controls.  Comparisons of psilocybin to LSD microdosers indicated no differences on measures of Depression, Anxiety and Stress from the DASS-21 (all values for F (1, 827) < 1.0, p > 0.50). The inclusion of…

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Using marijuana with psychedelics intensifies the mystical experience, study finds

Researchers at Imperial College London [report]… Use of cannabis together with psychedelics was “associated with higher scores of mystical-type experience, ego-dissolution and visual alterations,” the study, published last week in the journal Psychopharmacology, states. And in general, the more marijuana a person said they used, the more intense the psychedelic effect… there was a unique…

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…analog… psilocybin

…[ie] deuterated psilocybin analog has a duration of effect that is half is long as psilocybin, and a duration onset that is twice as fast. …[research pipeline seeking & developing] drugs with less variability [with goals such as] a faster onset time and better brain penetration that maintain the therapeutic properties of psilocybin and deliver…

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