Psilocybin… the human brain
Psilocybin was supplied by Usona Institute… (Open Science and Praxis Signatories) here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6–12 months later.
Psilocybin massively disrupted functional connectivity (FC) in cortex and subcortex, acutely causing more than threefold greater change than methylphenidate … psilocybin-driven FC changes were strongest in the default mode network (DMN), which is connected to the anterior hippocampus and is thought to create our sense of space, time and self … individual differences in FC changes were strongly linked to the subjective psychedelic experience … increased FC between the hippocampus and DMN has been associated with depression symptoms … and decreased FC is associated with treatment … these 5-HT2A receptor rich and depression associated default mode regions are candidates for mediating the neurotrophic antidepressant effects of psychedelics.
Original Article (Nature):
Psilocybin desynchronizes the human brain
Artwork Fair Use: EDELIC Center (ECfES.org)
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