In a groundbreaking study, researchers at the University of Michigan have found that a single dose of a psychedelic compound can significantly enhance cognitive flexibility, the brain’s ability to adjust to new information and changing circumstances, for several weeks. Using an innovative automated sequential learning paradigm, researchers evaluated how well mice could adapt to rule…
Certain psychiatric diseases, such as depression and schizophrenia, feature a loss of structures called dendritic spines from neurons. Dendritic spines form the receiving end of synapses, or connections between neurons. … the team tried switching the places of two atoms in LSD. This resulted in a compound that had the same 3D structure as LSD…
In this case, a team of neuroscientists and clinicians documented the effects of psilocybin on a 41-year-old woman in a minimally conscious state with language-mediated responses – referred to as MCS+. One year earlier, she had suffered a traumatic brain injury. People in this state show intermittent signs of awareness, such as following commands or…
Final participants are completing pre-dosing activities, including antidepressant medication washout where necessary. The trial is part of the largest randomized, controlled, double-blind psilocybin treatment clinical program ever conducted… COMP360 is being investigated as a potential… treatment for mental health conditions, administered with psychological support. Original Article (stocktitan):Compass Pathways announces completion of recruitment for the phase…
While large-scale studies are lacking, Mothers of the Mushroom gathered data points concerning mothers who ingested psilocybin during pregnancy and breastfeeding… offers insight from over 400 women who have used psilocybin while pregnant or breastfeeding… …[also] in a controlled study on pregnant rats using c-psilocin, no fetal fatalities were observed. While this does not confirm…
Poison control calls… most cases were relatively mild. Of callers who used hallucinogenic mushrooms, 28% reported minor or no effects on their health, 44% reported moderate impacts and 4% reported major problems. The most common complications were (presumably unpleasant) hallucinations or delusions; agitation; fast heart rate; nausea or vomiting; confusion; and pupil dilation. The most…
“Literally a grandma could take my video, watch it, and produce LSD,” says Willy. “This was like a fucking movie between the FBI contacting us and going to Pakistan. Just so many things had to line up correctly for this to happen, says Willy. “It’s never happened to date, and it’s been over 86 years…
The study, published in the Journal of Psychoactive Drugs, found that when administered under specific conditions, the mushroom extract restored spatial learning and memory impairments and increased levels of brain-derived neurotrophic factor (BDNF), a protein essential for brain plasticity. These effects were observed in rats subjected to a chronic unpredictable mild stress protocol, a widely used…
Researchers ran a double-blind, randomized trial in Washington State from February-December 2022. Their study was published in the Journal of the American Medical Association (JAMA) on December 5, 2024. This randomized clinical trial found that psilocybin therapy resulted in a significant, sustained reduction in symptoms of depression experienced by clinicians after frontline work during the…
[In December 2024]; a [new] synergistic, multi-level understanding of psychedelics; a novel, synergistic understanding of psychedelics arising from systematic reviews and meta-analyses of three hierarchical levels of analysis: (1) subjective experience (phenomenology), (2) neuroimaging and (3) molecular pharmacology. The Altered States of Consciousness (ASC) scale is one popular questionnaire that captures several of these subjective…
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