Psilocybin is formed by fungi in complex biochemical processes from the amino acid L-tryptophan. The enzyme PsiM, a methyltransferase, plays an important role in this process. It catalyzes two methylation reactions in succession, the last two steps in the production of psilocybin. …a team from the Medical University of Innsbruck led by crystallographer Bernhard Rupp and the…
…now corporations are stepping up to fund clinical trials. Although this support may help accelerate researchers’ understanding of psychedelics, it also sparks concern as a conflict of interest. Considering how to reduce the impact of conflicts of interest on psychedelic studies could help avoid public health risks… more awareness is needed for how corporate interests…
The culture surrounding psychedelic drugs has shifted significantly over the past few years, with voters in Colorado leading that charge… I was speaking from a place of deep love for the psychedelics field, and a conviction that we need to talk more about how the corporadelic empire has no clothes. In 2019, Denver became the first U.S.…
Scientific research has shown that there is a link between inflammatory processes in the body and depression. Several inflammatory markers have been linked to depression, including TNF-alpha, IL-6 and CRP. These are exactly the inflammatory markers that psilocybin has a good influence on. CRP, or C-reactive protein, is a natural inflammatory marker that increases in…
…mushroom extract demonstrated a stronger and more prolonged impact on synaptic plasticity… Metabolomic analyses indicated distinct metabolic profiles between the mushroom extract and synthetic psilocybin… Original Article (Neuroscience News & Nature):Mushroom extract outperforms synthetic psilocybin in psychiatric therapy & Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse…
Democratization of psychedelic chemistry and extraction methods, coupled with ubiquitously available and cheaply manufactured disposable vaporizer technology, has packed the most powerful known psychoactive substances into portable devices… DMT… 2C-B… [etc.] the long-term effects of vaping are largely unknown to science, let alone any potential adverse effects derived from the psychoactive chemicals being layered on…
“AlphaFold is an absolute revolution. If we have a good structure, we should be able to use it for drug design,” says Jens Carlsson, a computational chemist at the University of Uppsala in Sweden. Efforts to apply AlphaFold to finding new drugs have been met with considerable skepticism, says Brian Shoichet, a pharmaceutical chemist at…
“It’s a massive problem,” said Patrick Finan, the Harold Carron Professor of Anesthesiology in the School of Medicine and the co-principal investigator for the trial. “Chronic lower back pain is growing in prevalence, particularly as people age and medicine improves to keep people active longer.” Finan said there is encouraging research now that psilocybin may…
History has shown that developing enriched natural product elixirs or purified active agents, as with cocaine from the coca shrub and morphine from the opium poppy, can be both a blessing and a curse. Concentrated kratom extracts are analogous to these historical examples. Though the extracts may provide benefits to some, they may also result…
Researchers at Dalhousie University in Canada carried out a comprehensive review of the scientific literature, publishing their findings about marijuana as a preventive therapeutic in the Journal of Clinical Medicine… The study found that “cannabinoids have been shown to prevent viral entry, mitigate oxidative stress, and alleviate the associated cytokine storm” of early COVID-19 infections.…
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