Psilocybe cubensis mushrooms, one of the species most commonly consumed, are among the most heavily inbred… Cultivators are using genetic sequencing and are hybridizing cultivars from ever more distant lineages to hunt for improvements, plus sheer aesthetic novelty. Technological advancements have allowed for fungal cells to more easily be manipulated during breeding, and developments in chromatographic…
The results showed that the two pharmacological interventions created significantly different hierarchical reconfigurations of whole-brain dynamics… the main hypothesis is that psychedelics can bring about a relaxation of the precision of high-level priors or ‘beliefs’ (REBUS), allowing (anarchic) bottom–up information flow, consistent with ‘anarchic’ (that is, hierarchy-free) system dynamics. This theory is consistent with our…
Question: I heard magic mushrooms have strains, just like cannabis. Is that true? Answer: There are a lot of parallels between the two… and although they all have psilocybin, they’re not all the same. These mushrooms have other tryptamines and alkaloids… specific mushrooms have shown potential in treating specific mental and physical ailments, according to…
Researchers at the University of California, Davis have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs. The protein-based tool, which is called Ca2+-activated Split-TurboID, or CaST… This research provides scientists with a new technique that could be used to track step by step the molecular…
The study was conducted using 66 male Long-Evans rats, which were chosen based on their suitability for modeling human alcohol consumption behaviors. They were housed individually under a controlled light/dark cycle and had unlimited access to food and water. The study followed strict ethical guidelines for the care and use of laboratory animals. Initially, the…
“The ubiquity of fentanyl in the drug supply affords people who use drugs almost no margin of error if they make a dosing mistake,” Brandon del Pozo, an assistant professor (research) at Brown University’s Warren Alpert Medical School and School of Public Health said … …for decades, efforts by police to seize illicit drugs have…
Tianeptine has already become part of the nation’s struggle with opioids. Drug dealers have used it to make counterfeit hydrocodone and oxycodone pills… or to fill baggies made to resemble heroin packages. In their work, Jonathan Javitch, a professor at Columbia University and a research psychiatrist at the New York State Psychiatric Institute, Dali and…
In the U.S., the first wave of the long-running and devastating opioid epidemic began with the abuse of prescription painkillers (early 2000s); the second wave involved an increase in heroin use, starting around 2010. The third wave began when powerful synthetic opioids like fentanyl started appearing in the supply around 2015. Now experts are observing…
No toxic or lethal Psilocybe species are known. Evidence indicates that early hominids – our extinct ancestors – had been picking and eating “magic mushrooms” up to six million years ago. The practice likely influenced the development of human cognition and awareness, according to a recent review examining psilocybin’s effect on human consciousness… published in June 2024… recent studies have shown…
That study tracked internet search history on microdosing – a proxy for public interest – finding about a 1,250% increase since 2015. And searches for psilocybin started to outpace LSD in 2019… this type of data analysis has proven to be a reliable indicator for other drugs their lab has studied – including with novel…
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