Science

Shrooms and lsd linked to lower heart disease and diabetes risk

“The findings suggest that lifetime classic psychedelic use is associated with lower odds of having had heart disease or diabetes in the past year,” lead study author and Oxford sociologist Otto Simonsson, [said]. A team of scientists identified the unexpected trend after poring over ten years’ worth of data from the National Survey on Drug…

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Anthropology

…psychedelic… rush

The future of psychedelic therapy is also uncertain. While it seems likely that at least some psychedelic drugs will be approved for certain medical conditions in the years to come, it’s also possible that recreational use could be widely decriminalized or legalized. The status quo could also stay in place. The companies and people hoping…

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Science

Optimal dosing for psilocybin… considering weight-adjusted and fixed dosing approaches

Across a wide range of body weights (49kg [approx. 108lbs] to 113 kg [approx. 249lbs]) the present results showed no evidence that body weight affected subjective effects of psilocybin. In the 20 mg/70 kg and 30 mg/70 kg weight-adjusted groups, and in the fixed dose group, no significant associations were found between subjective effects and demographic variables including body weight…

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Politics

…rescheduling psilocybin

Citing the medical benefits of psilocybin, nine U.S. cities and the State of Oregon have decriminalized or legalized psilocybin… In Oregon, the Research Subcommittee of the Oregon Psilocybin Advisory Board, composed of physicians, biologists and public health officials, analyzed the research and concluded that “high quality phase [I and II] clinical trials suggest that psilocybin is efficacious…

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Biography/Memoir

[“Homebrewing”] psilocybin…

…the authors of the new study claim to have developed an extremely cheap method of producing psilocybin… “In less than [two] days, we successfully produced approximately 300 mg/L of psilocybin under simple conditions with easily sourced equipment and supplies,” write the study authors. “This work demonstrates the biosynthesis of psilocybin at concentrations in the 100s…

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Science

[National Institutes of Health 2021 grant]… Structure and function of G protein-coupled receptors [GPCR] heteromeric complexes in brain

Grant Project 5R01MH084894-12: Our published data and the preliminary data presented here support our working hypothesis that inter-family GPCR heteromerization affects structure, sub-cellular localization and function of both 5-HT2AR and mGluR2 in living mammalian cells. Our data are also consonant with the hypothesis that a single dose of hallucinogenic 5-HT2AR agonists induces fast-acting and long-lasting…

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Science

[National Institutes of Health 2021 grant…] the neural correlates of the effects of psilocybin in OCD: randomized controlled study

Funding from the National Institute of Health [NIH], which tends to award larger grants than philanthropists, allows researchers to delve more into the details, Johnson says. Grant Project Number 1K23MH122777-01A1: We hypothesize that psilocybin will result in increased (i.e. normalized) intra-DMN functional connectivity in OCD, and that this will correlate with any clinical change (Aim 1). Baseline…

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Science

[National Institutes of Health 2021 grant] …psilocybin in the treatment of tobacco use disorder

“The funding side of the government has been the last to the party for a long time,” says Matthew Johnson, who studies psychedelics at Johns Hopkins University. Grant Project Number 1U01DA052174-01A1: We hypothesize that psilocybin (compared to niacin) will cause increased biologically-confirmed 7-day point-prevalence abstinence at 12-month follow-up. Based on pilot data, we will test cognitive/psychological mediators…

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Science

[National Institutes of Health 2021 Grant]; psilcoybin in the treatment of tobacco use disorder…

“The funding side of the government has been the last to the party for a long time,” says Matthew Johnson, who studies psychedelics at Johns Hopkins University. Grant Project Number 1U01DA052174-01A1: We hypothesize that psilocybin (compared to niacin) will cause increased biologically-confirmed 7-day point-prevalence abstinence at 12-month follow-up. Based on pilot data, we will test cognitive/psychological mediators…

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