Science

[National Institutes of Health 2021 grant] …psilocybin in the treatment of tobacco use disorder

October 3, 2021By

“The funding side of the government has been the last to the party for a long time,” says Matthew Johnson, who studies psychedelics at Johns Hopkins University. Grant Project Number 1U01DA052174-01A1: We hypothesize that psilocybin (compared to niacin) will cause increased biologically-confirmed 7-day point-prevalence abstinence at 12-month follow-up. Based on pilot data, we will test cognitive/psychological mediators…

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Science

Stability of tryptamines in psilocybe… mushrooms

October 3, 2021By

…to prevent the degradation of alkaloids, the most suitable conditions were to dry the mushrooms whole and store in the dark at room temperature. Regardless of storage, rapid degradation of all tryptamines was observed in powder form. In the first month [re: powdered mushrooms] the greatest decrease occurred and through the second month the overall…

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[National Institutes of Health 2021 Grant]; psilcoybin in the treatment of tobacco use disorder…

October 3, 2021By

“The funding side of the government has been the last to the party for a long time,” says Matthew Johnson, who studies psychedelics at Johns Hopkins University. Grant Project Number 1U01DA052174-01A1: We hypothesize that psilocybin (compared to niacin) will cause increased biologically-confirmed 7-day point-prevalence abstinence at 12-month follow-up. Based on pilot data, we will test cognitive/psychological mediators…

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Science

How an expert psilocybin tester chooses award-winning mushroom

September 19, 2021By

To determine the amount of psilocybin and psilocin in each submission, the scientists… used a technology called High-Performance Liquid Chromatography (HPLC). …much like what happened with cannabis and THC, there’s been laser-focus on one compound in magic mushrooms – psilocybin. While it’s certainly important to understand the compounds that produce such a strong psychoactive effect, it’s also…

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…DMT increased growth of neurons by 40% in preclinical study at sub hallucinogenic dose

September 9, 2021By

Significant growth was also observed at concentrations as low as 100 picomolar. These concentrations are well below measured levels in humans required to achieve psychedelic breakthrough.  This initial data set is from… in vitro experiments designed to provide information on the dose and duration of infusion needed to achieve maximal cortical neurite outgrowth as well as…

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Science

Kratom: what does science say about the… botanical?

August 2, 2021By

A 2020 survey of 2,798 American Kratom users by Johns Hopkins Medicine found that less than 3% of respondents met the criteria for moderate or severe kratom use disorder… A 2019 study in Preventative Medicine estimated that “the risk of overdose death is >1000 times greater for opioids than for kratom.” While most morphine-like opiate overdoses are…

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Scientific study… suggests that kratom can suppress/kill cancer cells

July 31, 2021By

…the most interesting finding in this study is that Kratom by itself can suppress and kill cancer cells to a certain extent. [University Sains Malaysia study now on Pubmed]… since Big Pharma makes countless billions of dollars on cancer drugs/treatments, it is incredibly unlikely that any company would fund the research necessary to thoroughly ascertain…

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…health and epigenetic outcomes from a six-month naturalistic study

July 18, 2021By

…these findings are the first of their kind and consolidate indications that SIGMAR1 expression is regulated via an epigenetic process. results suggest that ayahuasca exposure affects the epigenetic regulation of SIGMAR1. However, the mean increase (2.1% increase) in DNA methylation is small, and it remains unclear if this change in DNA methylation has biological impacts…

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