…health and epigenetic outcomes from a six-month naturalistic study
…these findings are the first of their kind and consolidate indications that SIGMAR1 expression is regulated via an epigenetic process.
results suggest that ayahuasca exposure affects the epigenetic regulation of SIGMAR1. However, the mean increase (2.1% increase) in DNA methylation is small, and it remains unclear if this change in DNA methylation has biological impacts and alterations to gene expression. It is possible that an increase in SIGMAR1 DNA methylation enables increased expression of the receptor, however, this model is less likely, a common DNA methylation rules mean hypermethylation results in transcriptional silencing. At this stage, the implications of these findings are uncertain.
Original Article (Frontiersin):
Ceremonial ayahuasca in amazonian retreats—mental health and epigenetic outcomes from a six-month naturalistic study
Artwork Fair Use: Rasta, Abderrahim Rasta Hachimi