Science

How an expert psilocybin tester chooses award-winning mushroom

To determine the amount of psilocybin and psilocin in each submission, the scientists… used a technology called High-Performance Liquid Chromatography (HPLC). …much like what happened with cannabis and THC, there’s been laser-focus on one compound in magic mushrooms – psilocybin. While it’s certainly important to understand the compounds that produce such a strong psychoactive effect, it’s also…

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…DMT increased growth of neurons by 40% in preclinical study at sub hallucinogenic dose

Significant growth was also observed at concentrations as low as 100 picomolar. These concentrations are well below measured levels in humans required to achieve psychedelic breakthrough.  This initial data set is from… in vitro experiments designed to provide information on the dose and duration of infusion needed to achieve maximal cortical neurite outgrowth as well as…

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Kratom: what does science say about the… botanical?

A 2020 survey of 2,798 American Kratom users by Johns Hopkins Medicine found that less than 3% of respondents met the criteria for moderate or severe kratom use disorder… A 2019 study in Preventative Medicine estimated that “the risk of overdose death is >1000 times greater for opioids than for kratom.” While most morphine-like opiate overdoses are…

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Scientific study… suggests that kratom can suppress/kill cancer cells

…the most interesting finding in this study is that Kratom by itself can suppress and kill cancer cells to a certain extent. [University Sains Malaysia study now on Pubmed]… since Big Pharma makes countless billions of dollars on cancer drugs/treatments, it is incredibly unlikely that any company would fund the research necessary to thoroughly ascertain…

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…health and epigenetic outcomes from a six-month naturalistic study

…these findings are the first of their kind and consolidate indications that SIGMAR1 expression is regulated via an epigenetic process. results suggest that ayahuasca exposure affects the epigenetic regulation of SIGMAR1. However, the mean increase (2.1% increase) in DNA methylation is small, and it remains unclear if this change in DNA methylation has biological impacts…

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Active vs. passive coping distinguishes antidepressants and psychedelics

The potential for psychedelics to induce emotionally labile, or sensitive states, can be a great agent of therapeutic change (and can also lead to neuroplasticity and increased creativity). 5-HT1AR signaling offers basal control, moderating emotion and anxiety; 5-HT2AR signaling engages more during times of crisis.2 5-HT1A and 2AR signaling are endogenous pathways that drugs like…

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Just one dose of magic mushroom… regrows lost brain connections…

…triggered an immediate, long-lasting increase in neuronal connections after just a single dose. “We not only saw a 10 percent increase in the number of neuronal connections, but also they were on average about 10 percent larger, so the connections were stronger as well,” said neuroscientist Alex Kwan of Yale University. Original Article (Science Alert):Just one dose…

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The problem at the heart of modern psychedelic clinical research

For around half a century the randomized controlled trial (RCT) has been considered the gold standard in evaluating the effectiveness of any new medical intervention…. …does not suggest we need to abandon RCTs for psychedelic research … at least not yet… he calls for more rigor and transparency in the ways psychedelic trials are designed…

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