Science

How cannabis and psilocybin might help some of the 50 million Americans who are experiencing chronic pain

I want to help understand how to effectively use cannabis and psilocybin as potential tools for pain management. …lethal overdoses from cannabis are almost unheard of. This is remarkable considering that nearly 50 million Americans use it each year… a group of cannabis and pain specialists published a proposed guideline for clinical practice in early 2024 to…

READ MORE
Science

Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation

…in which a novel topological data analysis (TDA) method is applied to the neurophysiological study of the synergistic effects of meditation and psychedelics. …intriguing evidence of similarities in the phenomenology and neurophysiology of meditation and psychedelics has been found… recent reviews suggest that meditation and psychedelics exhibit similarities and complementary differences, which may indicate potential…

READ MORE
Science

Magic mushrooms can treat medication-resistant depression. Are they safe? A systemic review and meta-analysis

What are the notable acute adverse effects for therapeutic doses of psilocybin in the treatment of depression and anxiety? [Date Sources:] MEDLINE via PubMed, Web of Science, and ClinicalTrials.gov were searched for publications available between 1966 and November 30, 2023. In this meta-analysis of 6 randomized, double-blind clinical trials with 528 patients, headaches, nausea, anxiety,…

READ MORE
Science

Decoding psilocybin: “magical” enzymatic pathways…

Psilocybin is formed by fungi in complex biochemical processes from the amino acid L-tryptophan. The enzyme PsiM, a methyltransferase, plays an important role in this process. It catalyzes two methylation reactions in succession, the last two steps in the production of psilocybin. …a team from the Medical University of Innsbruck led by crystallographer Bernhard Rupp and the…

READ MORE
Science

How corporate involvement in psychedelic research could threaten public safety

…now corporations are stepping up to fund clinical trials. Although this support may help accelerate researchers’ understanding of psychedelics, it also sparks concern as a conflict of interest. Considering how to reduce the impact of conflicts of interest on psychedelic studies could help avoid public health risks… more awareness is needed for how corporate interests…

READ MORE
Science

…we learned from… status quo…

The culture surrounding psychedelic drugs has shifted significantly over the past few years, with voters in Colorado leading that charge… I was speaking from a place of deep love for the psychedelics field, and a conviction that we need to talk more about how the corporadelic empire has no clothes. In 2019, Denver became the first U.S.…

READ MORE
Science

[Psilocybe] mushroom extract outperforms synthetic psilocybin…

…mushroom extract demonstrated a stronger and more prolonged impact on synaptic plasticity… Metabolomic analyses indicated distinct metabolic profiles between the mushroom extract and synthetic psilocybin… Original Article (Neuroscience News & Nature):Mushroom extract outperforms synthetic psilocybin in psychiatric therapy & Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse…

READ MORE
Science

…psychedelic vape

Democratization of psychedelic chemistry and extraction methods, coupled with ubiquitously available and cheaply manufactured disposable vaporizer technology, has packed the most powerful known psychoactive substances into portable devices… DMT… 2C-B… [etc.] the long-term effects of vaping are largely unknown to science, let alone any potential adverse effects derived from the psychoactive chemicals being layered on…

READ MORE
Science

…thousands of possible psychedelics

“AlphaFold is an absolute revolution. If we have a good structure, we should be able to use it for drug design,” says Jens Carlsson, a computational chemist at the University of Uppsala in Sweden. Efforts to apply AlphaFold to finding new drugs have been met with considerable skepticism, says Brian Shoichet, a pharmaceutical chemist at…

READ MORE