Science

[Beer… coffee… fentanyl…]

….beer twice as expensive… That’s because the cost of a key ingredient, malted barley, could soar as…barley becomes harder to grow. The price of a six-pack in the United States might rise by as much as $8 on average, the study found… [coffee] six-in-ten of the known species of coffee are now under threat of…

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Politics

Patents… legal battlefront…

To be eligible for patent protection, an invention must be a “process, machine, manufacture, or composition of matter.” Moreover, it must not fall into one of three categories of excluded subject matter, the so-called judicial exceptions to patent eligibility, which include laws of nature, abstract ideas, and natural phenomena. This animating principle excludes naturally occurring psychedelics, and the…

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Science

Anti-inflammatory effects of four psilocybin-containing magic mushroom [psilocybe & panaeolus] water extracts 

Mushrooms were grown and extracted with boiling hot water. Effects of the four water extracts on 15-LOX activity were determined… natural [fungi] with medicinal properties have been used to treat all sorts of inflammatory conditions and studies have shown that natural products have advantageous structural diversity over synthetic compounds, which thus make them a potential…

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Science

Comparing… mushrooms and truffles…

…psilocybin truffles have “a lot of psilocybin but little psilocin.” This hypothesis is corroborated in the literature. …, Pellegrini et al. reported: “…no trace of psilocin could be found at least at the limit of the detection of the assay” (0.3 µg per 100 mg truffles). In stark contrast, a 2019 study… found that a…

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Science

…to define…

So what has science been able to offer since Shulgin? There have been at least two contributions to the field: The first is the structural determination of a psychedelic-bound 5-HT2A receptor at near-atomic resolution. These reconstructions have enabled detailed computer simulations to identify thousands of candidate compounds which can be tested to evaluate their kinetic…

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Medicine/Healing

Why magic mushroom dispensaries are popping up…

[“We need a civil rights movement for your consciousness,” said Paul Stamets in a TED2022 talk] …there are colourful new signs advertising magic mushrooms for sale inside… that’s been operating in the neighbourhood for years. Walking up a few stairs and through Mushroom Cuts‘ glass doors, you’ll see two salon chairs framed with neon lights…

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Science

Myriad new drugs…

…by definition, the compounds are new and poorly understood… most people who use drugs wouldn’t want to use most NPS anyway, if better-known and better-studied equivalents were legally and widely accessible. An effort out of the University of Copenhagen called HighResNPS collects mass spectrometry data on novel psychoactive substances (NPS) from around the world. Its list, which…

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