Science

The 25 biggest scientific breakthroughs of 2017

Number 24. Magic mushrooms can help with depression. Scientists put tripping patients into fMRI machines to observe what their brains did under the influence of psilocybin, the active ingredient in hallucinogenic, “magic,” mushrooms. They found that patients with depression described feeling “reset” after a trip, and brain scans supported this conclusion. Patients who reported feeling…

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Clinical review: Psilocybin therapy could be significantly better than current psychiatric treatments

Thomas and his two colleagues, Benjamin Malcolm and Dan Lastra, came to this conclusion after reviewing seven clinical trials on psilocybin-assisted therapy. These previous studies were published over the past decade and examined cancer-related anxiety, obsessive-compulsive disorder, depressive disorders, and addiction. “This therapy has also demonstrated large effect sizes for improving symptoms on validated psychiatric…

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Is Kratom the CBD of opioids?

*Peace Monument in Washington D.C. Could Kratom be the CBD of the opiate world? … Ironically, the greatest danger of Kratom these days is from fake products contaminated with substances approved by the FDA. In rats, there was no observed toxicity following single, huge oral doses up to 806 mg/kg of [mitragyine]. (CBD is also…

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National expert: no cases show deaths solely from coffee-like herb kratom, which should be handled no differently than other substances

“…kratom… has not been linked to any known deaths, and the plant has little potential for abuse and dependence – as low or lower than such widely used (and federally unscheduled substances) as “nutmeg, hops, St. John’s Wort, chamomile, guarana, and kola nut.” -Dr. Henningfield* Dr. Henningfield previously served as chief of the Clinical Pharmacology…

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Posttreatment brain effects of psilocybin in patients with treatment-resistant depression

Changes in resting-state brain blood flow and functional connectivity following the use of psilocybin in patients with treatment-resistant depression have been documented for the first time, according to the results of a recent open-label UK study published in Scientific Reports. Investigators collected functional magnetic resonance imaging (fMRI) data from patients with treatment-resistant depression in order…

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What LSD tells us about human nature

Healthy volunteers were injected with LSD while lying in an MRI scanner, and subjected to several other neuroimaging methods at the same time. This amounted to an arsenal of measurement that previous decades of psychedelic researchers could only dream of. ​Humans have gathered, cultivated, distilled, and manufactured all kinds of drugs for thousands of years.…

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Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

This study was approved by the National Research Ethics Service (NRES) committee London – West London and was conducted in accordance with the revised declaration of Helsinki (2000), the International Committee on Harmonisation Good Clinical Practice (GCP) guidelines and National Health Service (NHS) Research Governance Framework. Imperial College London sponsored the research which was conducted…

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Legal MDMA could soon be a thing

Don’t go thinking that ecstasy bought on the streets is good for you though, laboratory studies have shown that only pure MDMA has been proven sufficiently safe for human consumption when taken a limited number of times in moderate doses. ​ After extensive research, the U.S. Food and Drug Administration (FDA) has now confirmed it’s…

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