…the last thing we did was to play around with the genetic code of the Psilocybe genes a little bit so that we could divert production towards some of the other intermediates and derivatives of the pathway… …we had to dig a little bit into the genome of Psilocybe cubensis to find the missing genes. We then introduced them…
Psilocybin has a quirky advantage for researchers over and above LSD and MDMA, according to Dr. David Nutt, a physician and Professor of Neuropsychopharmacology at Imperial College. In a world grappling with… isolation, mushrooms, especially… [psilocybe] mushrooms, offer a connection to the natural world, forging community, and healing in ways that modern pharmaceuticals, even psychedelic…
Since time immemorial, people have used psychedelics for spiritual development, personal growth and expanded creativity. But rigorous research on psychedelics for self-improvement is only just starting to pick up steam. Without any clear business model emerging around psychedelics for creativity, and the large-scale regulatory changes that are necessary for the legal, non-medical use of psychedelics,…
You can’t blame people for wanting the expansive and often life-changing jolt that 5-MeO-DMT can deliver. But this kind of transcendence comes at a cost. The practice of collecting defensive secretions from toad parotoid glands isn’t a pretty sight. It often involves harassment of the animal that leads to mutilating them and destruction of their habitats.…
…can cannabis equipment be used for mushroom extraction? Psilocybin and cannabis are polar opposites – literally. Cannabinoid molecules are nonpolar, while psilocybin is… because cannabinoids are nonpolar molecules, typically extracted through CO2, hydrocarbon, butane or ethanol, that equipment wouldn’t suffice to extract a polar molecule, like psilocybin. There are some exceptions, however… natural extraction methods…
Polymorphs B, A, and H… supported through Usona as an open access paper… peer-reviewed study… shows three most pharmaceutically relevant crystalline forms of psilocybin have been consistently created and observed since 1959. The ability of a unique crystalline arrangement to solidify in more than one form, called polymorphs, can be optimized using precise combinations of…
…microdosing psychedelics is technically not substance misuse because it does not involve taking drugs in excess or for an unintended purpose. The practice of microdosing psychedelics dates back to at least the early 16th century… to relieve fevers and rheumatism. The accepted definition of substance misuse is the use of prescription, illegal drugs, or over-the-counter drugs or…
Known as the Systematically Testing the Evidence on Marijuana… the project is a joint production of researchers with Oregon Health & Science University’s (OHSU) Center for Evidence-based Policy and the Veterans (VA) Portland Health Care System. …designed as an independent, methodologically rigorous resource primarily for health care workers. The site features living systematic reviews that…
Given the strikingly similar DMT entities reported by unconnected people from around the world, scientists are now attempting to understand more about the nature of these psychedelic characters… …a study… of the 2,561 DMT users surveyed by the Johns Hopkins team, 65 percent said their encounter filled them with “joy”, while 63 percent experienced a…
…repeatedly microdosed… zebrafish with LSD.… …using behavioural neuroscience tests to quantify locomotion, boldness and anxiety-like behaviour… we [also] found that zebrafish acutely dosed with the terpene limonene (found in citrus fruit peels and cannabis) and myrcene (found in cannabis and hops), showed a significant reduction in anxiety-like behaviour… [with terpene limonene & myrcene] no negative…
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