Researchers ran a double-blind, randomized trial in Washington State from February-December 2022. Their study was published in the Journal of the American Medical Association (JAMA) on December 5, 2024. This randomized clinical trial found that psilocybin therapy resulted in a significant, sustained reduction in symptoms of depression experienced by clinicians after frontline work during the…
[In December 2024]; a [new] synergistic, multi-level understanding of psychedelics; a novel, synergistic understanding of psychedelics arising from systematic reviews and meta-analyses of three hierarchical levels of analysis: (1) subjective experience (phenomenology), (2) neuroimaging and (3) molecular pharmacology. The Altered States of Consciousness (ASC) scale is one popular questionnaire that captures several of these subjective…
…performed single-nucleus RNA sequencing in psychedelic-activated neurons in mouse medial prefrontal cortex. The psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5HT2A receptor agonist with anxiolytic-like effects in mice, activated a specific subset of neurons in this brain region. Equipped with a fluorescent map of the neurons activated by DOI, the team [David E. Olson, et. al]… used optogenetics,…
“Most psychedelic research has focused on the brain, but I became increasingly convinced that we were overlooking something crucial. This idea was reinforced by the growing field of somatic therapy and the way psychedelics seem to help reconnect people’s minds with their bodies,” said study author Valérie Bonnelle, an independent researcher who received a PhD…
“Almost 100% of our drug supply is fentanyl and 80% to 90% of that fentanyl is adulterated with xylazine,” said Dr. Elizabeth Krans, a physician and researcher at UPMC Magee-Womens Hospital in Pittsburgh. Xylazine is a potent animal tranquilizer normally used by veterinarians. For reasons that aren’t completely clear, drug gangs began mixing it into…
In a new study published in Molecular Plant, Weizmann Institute of Science researchers have made the first, crucial move toward ensuring sustainable production of mescaline: They have revealed, step by step, how exactly it is manufactured in peyote. “Learning how to copy this natural process with biotechnology will help ensure a steady supply of mescaline for the development…
Psilocybe cubensis mushrooms, one of the species most commonly consumed, are among the most heavily inbred… Cultivators are using genetic sequencing and are hybridizing cultivars from ever more distant lineages to hunt for improvements, plus sheer aesthetic novelty. Technological advancements have allowed for fungal cells to more easily be manipulated during breeding, and developments in chromatographic…
The model revealed that after receiving psilocybin, rats achieve more rewards through increased task engagement… As optimism bias is associated with increased engagement with the world and depression is linked to diminished optimism… all experimental procedures were conducted in accordance with the Australian Code for the care and use of animals for scientific purposes and…
The results showed that the two pharmacological interventions created significantly different hierarchical reconfigurations of whole-brain dynamics… the main hypothesis is that psychedelics can bring about a relaxation of the precision of high-level priors or ‘beliefs’ (REBUS), allowing (anarchic) bottom–up information flow, consistent with ‘anarchic’ (that is, hierarchy-free) system dynamics. This theory is consistent with our…
Question: I heard magic mushrooms have strains, just like cannabis. Is that true? Answer: There are a lot of parallels between the two… and although they all have psilocybin, they’re not all the same. These mushrooms have other tryptamines and alkaloids… specific mushrooms have shown potential in treating specific mental and physical ailments, according to…
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