Science

Hemp extraction to mushroom extraction?

…can cannabis equipment be used for mushroom extraction? Psilocybin and cannabis are polar opposites – literally. Cannabinoid molecules are nonpolar, while psilocybin is… because cannabinoids are nonpolar molecules, typically extracted through CO2, hydrocarbon, butane or ethanol, that equipment wouldn’t suffice to extract a polar molecule, like psilocybin. There are some exceptions, however… natural extraction methods…

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…controlled crystal engineering process for large-scale synthesis of psilocybin polymorphs

Polymorphs B, A, and H… supported through Usona as an open access paper… peer-reviewed study… shows three most pharmaceutically relevant crystalline forms of psilocybin have been consistently created and observed since 1959. The ability of a unique crystalline arrangement to solidify in more than one form, called polymorphs, can be optimized using precise combinations of…

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Science

What to know about microdosing…

…microdosing psychedelics is technically not substance misuse because it does not involve taking drugs in excess or for an unintended purpose. The practice of microdosing psychedelics dates back to at least the early 16th century… to relieve fevers and rheumatism. The accepted definition of substance misuse is the use of prescription, illegal drugs, or over-the-counter drugs or…

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[Oregon university & veterans administration]… cannabis resource for health care providers

Known as the Systematically Testing the Evidence on Marijuana… the project is a joint production of researchers with Oregon Health & Science University’s (OHSU) Center for Evidence-based Policy and the Veterans (VA) Portland Health Care System. …designed as an independent, methodologically rigorous resource primarily for health care workers. The site features living systematic reviews that…

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Science

why do people see elves and other “entities”… DMT…

Given the strikingly similar DMT entities reported by unconnected people from around the world, scientists are now attempting to understand more about the nature of these psychedelic characters… …a study… of the 2,561 DMT users surveyed by the Johns Hopkins team, 65 percent said their encounter filled them with “joy”, while 63 percent experienced a…

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Microdosing zebrafish… shows its potential benefits for humans

…repeatedly microdosed… zebrafish with LSD.… …using behavioural neuroscience tests to quantify locomotion, boldness and anxiety-like behaviour… we [also] found that zebrafish acutely dosed with the terpene limonene (found in citrus fruit peels and cannabis) and myrcene (found in cannabis and hops), showed a significant reduction in anxiety-like behaviour… [with terpene limonene & myrcene] no negative…

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Science

Drug testing: dramatic drop in bath salts being sold as MDMA

In a statement, Police National Drug Intelligence Bureau Manager Blair Macdonald said he was pleased with how this summer’s festival season had taken shape. …the Drug and Substance Checking Legislation Act, which was passed by Parliament in November 2021, has created a safer environment for people to get their drugs checked before they choose to…

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…patent challenge targets crystallography errors

In the paper, the authors highlight errors they discovered in the patent granted to COMPASS Pathways… COMPASS fell victim to that problem by not distinguishing between different crystalline forms. In other words, COMPASS fell victim to the problem it claimed to solve. The Petition claims that COMPASS Pathways never reported the crystal structure for its…

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…open science approach to… MDMA [& psilocybin]

Instead of holding on tightly to trade secrets… MAPS paper… read as a step-by-step production recipe, the study maps out how MDMA with a purity of 99.4% can be made from non-controlled substances… describes a process of making MDMA according to “current Good Manufacturing Processes” (cGMP), with the end product being 30.000 (167mg) individual doses……

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Now psychedelics are coming to your medicine cabinet

Adding psychedelics to mainstream drugs may seem a bit “out there,” but in fact it’s on trend… Synthetic versions of psychedelic substances are easier to manufacture uniformly according to industry standards, but they may not work as well as natural versions. “We believe there’s a big difference between biological and synthetic molecules, especially in how…

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