As psychedelics re-enter mainstream, with psilocybin legalized for recreation in Colorado, and for therapeutic use in Oregon, millions of Americans are trying them for the first time, and some are walking away – quite by surprise – true believers. In stumbling upon the connection between mushrooms and the sacred, Brinkerhoff and Worwood are discovering a…
The results showed that the two pharmacological interventions created significantly different hierarchical reconfigurations of whole-brain dynamics… the main hypothesis is that psychedelics can bring about a relaxation of the precision of high-level priors or ‘beliefs’ (REBUS), allowing (anarchic) bottom–up information flow, consistent with ‘anarchic’ (that is, hierarchy-free) system dynamics. This theory is consistent with our…
Question: I heard magic mushrooms have strains, just like cannabis. Is that true? Answer: There are a lot of parallels between the two… and although they all have psilocybin, they’re not all the same. These mushrooms have other tryptamines and alkaloids… specific mushrooms have shown potential in treating specific mental and physical ailments, according to…
The study was conducted using 66 male Long-Evans rats, which were chosen based on their suitability for modeling human alcohol consumption behaviors. They were housed individually under a controlled light/dark cycle and had unlimited access to food and water. The study followed strict ethical guidelines for the care and use of laboratory animals. Initially, the…
Van der Merwe and colleagues’ paper documents the two discoveries, while also featuring insights on the medicinal use of P. maluti by Basotho traditional healers. Van der Merwe and colleagues’ paper documents the two discoveries, while also featuring insights on the medicinal use of P. maluti by Basotho traditional healers… this study is the only recorded firsthand report of…
No toxic or lethal Psilocybe species are known. Evidence indicates that early hominids – our extinct ancestors – had been picking and eating “magic mushrooms” up to six million years ago. The practice likely influenced the development of human cognition and awareness, according to a recent review examining psilocybin’s effect on human consciousness… published in June 2024… recent studies have shown…
That study tracked internet search history on microdosing – a proxy for public interest – finding about a 1,250% increase since 2015. And searches for psilocybin started to outpace LSD in 2019… this type of data analysis has proven to be a reliable indicator for other drugs their lab has studied – including with novel…
A recent survey of 3,294 US adults, aged between 42 and 92, has found that… compared to those who did not use psychedelics, those who did scored higher on tests… which assessed inductive reasoning, verbal fluency, working memory, processing speed, attention switching, and inhibitory control. Psilocybin, LSD, MDMA, and other psychedelics appear to stimulate new connections between…
…if someone is desperate and suicidal, of course they should be able to try psychedelics, as quickly and safely as possible. The healthcare system is broken, the FDA approval system is slow and very expensive…and people can sometimes heal themselves outside of the medical system. Clusterbusters is a really interesting example of a peer support group which…
A year in, Oregon’s experiment with the first regulated psilocybin mushroom market in the world is short on customers. …a year of challenges, red tape and waning interest in guided mushroom trips under Oregon’s… legal model… to date, roughly 3,500 clients [from primarily out-of-state] have taken a supervised trip in one of Oregon’s 25 psilocybin…
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