Science

Magic mushrooms can treat medication-resistant depression. Are they safe? A systemic review and meta-analysis

What are the notable acute adverse effects for therapeutic doses of psilocybin in the treatment of depression and anxiety? [Date Sources:] MEDLINE via PubMed, Web of Science, and ClinicalTrials.gov were searched for publications available between 1966 and November 30, 2023. In this meta-analysis of 6 randomized, double-blind clinical trials with 528 patients, headaches, nausea, anxiety,…

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Science

Decoding psilocybin: “magical” enzymatic pathways…

Psilocybin is formed by fungi in complex biochemical processes from the amino acid L-tryptophan. The enzyme PsiM, a methyltransferase, plays an important role in this process. It catalyzes two methylation reactions in succession, the last two steps in the production of psilocybin. …a team from the Medical University of Innsbruck led by crystallographer Bernhard Rupp and the…

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Science

…we learned from… status quo…

The culture surrounding psychedelic drugs has shifted significantly over the past few years, with voters in Colorado leading that charge… I was speaking from a place of deep love for the psychedelics field, and a conviction that we need to talk more about how the corporadelic empire has no clothes. In 2019, Denver became the first U.S.…

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Psychology

Use of psilocybin for mental health treatment ‘not associated’ with risk of paranoia, American Medical Association study finds

While psychedelics are sometimes portrayed in media as causing intense paranoia, particularly in a recreational setting, the study authors said psilocybin “was not associated with risk of paranoia and transient thought disorder.” The researchers identified five other reported adverse effects among certain patients in the clinical trials: headache, nausea, anxiety, dizziness and elevated blood pressure.…

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Modern Culture

Steps… safely… psychedelics

…crucial steps to help you see the lay of the land in Colorado’s quickly evolving world of…. legal psychedelic gifting portals across Colorado… unlicensed psychedelics. Home grows and extraction processes are how a large portion of… psychedelics find their way to users. If you’re not cultivating or creating these psychedelics yourself, it’s crucial to know…

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