For the study, participants either received 10mg of escitalopram daily for seven days followed by 20mg daily for the next seven days, including the day of psilocybin administration, or 14 days of placebo pre-treatment before psilocybin administration. The researchers found that pre-treatment with escitalopram did not alter the pharmacokinetics of psilocin — the active compound that the…
Despite the seriousness of those findings, acetaminophen nonetheless remains one of the most used medications in the world, considered an essential medicine by the World Health Organization, and recommended by the CDC for pain relief at home… the findings are reported in Social Cognitive and Affective Neuroscience. “Acetaminophen seems to make people feel less negative emotion when they…
In order to have physical dependence your body needs to start relying on a substance to function properly. …there does not appear to be any sort of physiological mechanism that would make your body “dependent” on psilocin in such a way that you’d experience physical effects from stopping a regimen. In other words, no, you’re…
This examination of a large international sample of adults highlights the prominence of therapeutic and wellness motivations for microdosing psychedelic drugs and identified lower levels of anxiety and depression among microdosers relative to controls. Comparisons of psilocybin to LSD microdosers indicated no differences on measures of Depression, Anxiety and Stress from the DASS-21 (all values for F (1, 827) < 1.0, p > 0.50). The inclusion of…
…[ie] deuterated psilocybin analog has a duration of effect that is half is long as psilocybin, and a duration onset that is twice as fast. …[research pipeline seeking & developing] drugs with less variability [with goals such as] a faster onset time and better brain penetration that maintain the therapeutic properties of psilocybin and deliver…
…a 35-percent response rate and a 5-percent SAE rate means for every seven patients positively responding to the treatment, one person will experience serious negative outcomes… these serious adverse events included suicidal ideation and suicidal behavior. Five patients (6.3 percent) in the 25-mg group and six patients (8 percent) in the 10-mg group experienced at…
With… propriety technology… stable formulations of both psilocin and psilocybin from magic mushrooms. …drug development efforts are focused exclusively on extracting, purifying, and standardizing natural psychedelic compounds. Original Article (Psychedelic Spotlight):FDA approves first clinical trial using naturally sourced psychedelicsArtwork Fair Use: Perdula
…the variability of compounds in magic mushrooms… environmental variables such as light and the type of growing medium influence the presence and amount of certain compounds… in the mushroom fruiting bodies… …isolated and tested for multiple compounds of interest in the mushroom including the tryptamine alkaloids: baeocystin, norbaeocystin, norpsilocin, aeruginascin, 4-HO-TMT, 4-hydroxytryptamine. The beta-carbolines: harmine, harmane, norharmane, harmol. Original Article (Psychedelic Science…
…the minutes-long hallucinogenic and dissociative effects of recreational S. divinorum in humans have been described in detail. Salvia divinorum… inhibited contractions of the mouse colon, stomach, and ileum in vitro; prolonged colonic propulsion; and slowed upper GI transit in vivo by activating KOR, CB1, and interestingly by activating cannabinoid type 2 receptors (CB2). In our laboratory, we…
“The findings suggest that lifetime classic psychedelic use is associated with lower odds of having had heart disease or diabetes in the past year,” lead study author and Oxford sociologist Otto Simonsson, [said]. A team of scientists identified the unexpected trend after poring over ten years’ worth of data from the National Survey on Drug…
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