…psychedelics spurred new growth in both baby and mature neurons. But the mind-bending substances were 1,000 times more efficient than Prozac at grabbing onto a key molecular hub, TrkB. With just a single dose, the drugs elevated mood in mice under chronic stress and reduced a previously-established fear. Psychedelics produce fast and persistent antidepressant effects…
“We disproved our initial hypothesis that psychedelic states (here with psilocybin) produce higher complexity,” Ort explained. “Unlike the observed reduction of complexity during dreamless sleep, anesthesia or minimally conscious states, the psychedelic state has the same quantitative complexity as in normal waking – even though the quality of the conscious experience has massively changed.” Ort…
The Elliptic report notes that the tens of millions of dollars worth of precursor sales it tracked on blockchains would likely be enough to manufacture enough fentanyl to, if distributed efficiently, kill every person on earth… the US government may be increasingly aware of the activity of fentanyl precursor sellers in China and of cryptocurrency’s…
When consuming psilocybin mushrooms, it’s important to consider the development of tolerance. Tolerance refers to the body’s adaptation to the effects of a substance, resulting in a diminished response over time. The tolerance that builds with psilocybin is specifically called tachyphylaxis, which is a rapidly diminishing response to successive doses of a drug, thus rendering it…
After self-administering a color blindness test, known as the Ishihara Test, the subject took five grams of dried mushrooms, which is considered a relatively high dose of psilocybin. He then took the Ishihara Test periodically over the next four months. This test is composed of a series of flashcards that each feature a number made…
…potential adaptive advantages psiloids may confer to fungi. Fungi produce diverse metabolites that can have antimicrobial, antifungal, antifeedant, or psychoactive properties. Among these metabolites are the tryptamine-derived compounds psilocybin, its precursors, and natural derivatives (collectively referred to as psiloids), which have played significant roles in human society and culture. Original Article (SSRN):The evolution and ecology…
Where we have two traditionally recognized genders, male and female, some species of fungi can have thousands of sexes… to mate, all a fungus has to do is bump up against another member of its species and let their cells fuse together. It sounds confusing, but it’s actually helpful – with so many variations, the…
The researchers highlight that while their study is not the first to image the brain under the influence of psychedelics or the first to show the signatures of brain activity linked to psychedelics, it is the first to combine imaging techniques to study the brain during a highly immersive psychedelic experience. The fMRI scans found…
Perhaps the most important conclusion which can be drawn from the present analysis is that most kinds of illicit drug use are nowhere near as lethal as would be assumed from reading mass media reports or heeding government warnings, and that two of our three legal psychoactive drugs, alcohol and tobacco, are far more likely…
Indigenous use of psychedelic plants may have played a significant role in developing and maintaining spiritual, animistic, and religious beliefs; during the countercultural movement in the ’60s, the popularity of LSD may have been a significant catalyst in the proposed transformation of society’s norms and values. These examples appear to suggest that psychedelics may profoundly affect…
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