Science

How long to wait between mushrooms trips…

When consuming psilocybin mushrooms, it’s important to consider the development of tolerance.

Tolerance refers to the body’s adaptation to the effects of a substance, resulting in a diminished response over time. The tolerance that builds with psilocybin is specifically called tachyphylaxis, which is a rapidly diminishing response to successive doses of a drug, thus rendering it less effective with each dose… biologically, research indicates that it takes approximately 7-14 days for psilocybin tolerance to reset fully. During this period, the brain’s serotonin receptors (5-HT2A) gradually return to their baseline sensitivity. Waiting for tolerance to reset allows individuals to embark on subsequent mushroom trips with renewed receptiveness, ensuring a fresh and unaltered experience.

Original Article (Psychedelic Spotlight):
How long to wait between mushrooms trips for optimal results
Artwork Fair Use: Dafne Cholet

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