Science

Active vs. passive coping distinguishes antidepressants and psychedelics

The potential for psychedelics to induce emotionally labile, or sensitive states, can be a great agent of therapeutic change (and can also lead to neuroplasticity and increased creativity).

5-HT1AR signaling offers basal control, moderating emotion and anxiety; 5-HT2AR signaling engages more during times of crisis.2 5-HT1A and 2AR signaling are endogenous pathways that drugs like antidepressants and psychedelics can stimulate. Researchers employ the terms “passive” vs. “active” coping to these two serotonin signaling pathways. The dual model suggests that under passive coping one tolerates but does not “deal with” a source of psychological distress whereas during active coping one actively deals with psychological distress and can even change their relationship to it.

Original Article (Psychedelic Review):
Active vs. Passive coping distinguishes antidepressants and psychedelics
Artwork Fair Use: Czeva

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