LSD administered as a single dose reduces alcohol consumption in… mice

This present research focuses on the effect of LSD on alcohol intake in a two-bottle choice drinking paradigm in C57BL/6J mice, an inbred alcohol-preferring strain (Melo et al., 1996).

In the group treated with 50 μg/kg LSD, mean daily ethanol consumption was 13.62 ± 3.02 g/kg/day compared to 16.60 ± 3.52 g/kg/day (mean ± SD) in controls (t = -1.86, df = 15, p = 0.0414), and ethanol preference was 0.493 ± 0.104 versus 0.580 ± 0.091 in controls (t = -1.83, df = 15, p = 0.0436), a 17.9% reduction in the LSD-treated animals, without a significant difference in mean daily total fluid intake. The group treated with 25 μg/kg LSD did not differ from control group with regard to mean daily ethanol consumption or preference, or total fluid intake … This study found reductions in both ethanol consumption and preference in the group of mice treated with the LSD dosage of 50 μg/kg. Although the magnitude of effect on ethanol consumption was limited, with a group mean reduction of 17.9%, it was sustained across a time interval of 46 days.

Original Article (Frontiers):
LSD administered as a single dose reduces alcohol consumption in… mice​
Artwork Fair Use: Ben Mills

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