Estrogen impacts the effects of psilocybin for women
We are left behind in mainstream medical system and so when you when we want to discuss these things… women have had a lot of difficulty in the mainstream medical system—and that’s not to say that I have a problem with the mainstream medical system—however, there is a history of women being gaslit at the doctor’s office for chronic pain and other conditions… We know that estrogen can affect binding at the serotonin receptor sites… with microdosing there are a bunch of different protocols out there… if you are considering microdosing to follow whatever protocol that you choose for 3 months and keep track of some of the effects that are happening, if you’re having a change in symptoms, or just how you generally feel. It’s best to try that before deciding if it is or isn’t working or just continuing on…it will give you more knowledge than if you just a 3 week microdose session and then quit.
…menstrual cycles occur along the hypothalamic-pituitary-gonadal (HPG) axis, so as one hormone kicks off, it tells another hormone what to do in this feedback loop and that’s the trajectory of our menstrual cycles. We also have the axis that manages our stress response, the hypothalamic-pituitary-adrenal (HPA) axis. These two axes sort of overlap, and so they each impact one another. When we use psilocybin, we are at doing something along that stress response along the HPA axis. We already know from research outside of psychedelics, that these two axes do impact each other: our stress response can impact our cycle, and our cycles can impact our stress response. So, it’s not a stretch to think that when we are using psilocybin, that something is going on with our stress response that then impacts the menstrual cycle, or where we are in our cycle matters for the type of trip that we have if we’re journeying on a deeper dose… I see a lot of promise for psilocybin within the realm of parenting. Some parents are actually using psilocybin to better connect with their kids, for example, a parent might do their own solo psilocybin journey, then later, the brain becomes more entropic during a psilocybin journey—and then there’s some beneficial effects for entropy after a psilocybin journey—that makes your brain more flexible when getting back to that state of childlike wonder and awe. Then parents come back together with their kids and are finding that they are enjoying play a little differently in terms of, “Yeah, I want to get down on the floor and put those Legos together, I want to do some art with my kid.” It can be a challenge when you’ve got so many things going on in your life and you’re busy to get to that state of childlike wonder and really focus on being present and having fun playing with your kids. So, there’s some potential there, I’ve heard from parents that that’s what they’re doing.
Original Article (Pharmacy Times):
Estrogen impacts the effects of psilocybin for women
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