…work, in part, in a similar way to traditional antidepressants - they affect the chemical pathways in the brain involving serotonin (the hormone that influences mood and can make us feel good).
However, they also have a range of other beneficial biological activities, like anti-inflammatory effects… our analysis shows that medicinal psychedelics have a statistically significantly superior effect to placebo on improving negative mood outcomes and symptoms of depression over the short-term (three hours to one day after treatment) and longer-term (16 to 60 days after treatments) for patients with a mood disorder. The best results for depressive symptoms were achieved within two-to-seven days. Additionally, short-term mood enhancement was also observed for people who were mentally healthy and didn’t have depression.
Original Article (University of Melbourne):
Psychedelic medicine : a mental health game changer?
Artwork Fair Use: Ji-Elle