[Whole plant kratom] has a… following of people who take it for addiction — and researchers say it’s too compelling to ignore

*Hemby is the author of a new study on kratom published in the journal Addiction Biology, and his results suggest that the chief compound in the plant could offer therapeutic benefits.

“It makes sense that this product [kratom] would mitigate the symptoms of opioid withdrawal or allow someone to transition from a higher dose to lower dose, or help get off them off of opioids altogether,” David Juurlink, a professor of medicine at the University of Toronto, [said]… “We’re at the precipice of something promising here,” Scott Hemby, a professor of pharmaceutical science at High Point University in North Carolina [said]  “It’s kind of the yin and yang of kratom,” Hemby said.

Mitragynine, or MG, is thought to be the compound with the most therapeutic potential. It is also present in kratom in much higher concentrations than HMG. MG makes up roughly 60% of this type of compound in the plant, while HMG only makes up about 2%. Hemby’s study is the first to use rats to investigate how each of these two compounds affects the brain. He and his colleagues gave the animals the chance to self-administer each component of kratom by pushing a dial — first HMG, and then MG. They found that the rats quickly took advantage of the opportunity to give themselves the compound HMG, but they were completely uninterested in MG. “We stood on our heads to get them to self-administer,” Hemby said, adding that his team tried upping the doses of MG several times. “It just wasn’t working. It was almost like it was innocuous.” In other words, while one of kratom’s main compounds appeared to be addictive, the other wasn’t at all — in fact, it appeared to have the opposite effect.

The Entourage Effect : Of Kratom?  HERE

From the Article (Business Insider):
A mysterious supplement has a viral following of people who take it for addiction — and researchers say it’s too compelling to ignore
Artwork Fair Use: EwigLernender




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