Top Kratom researcher discusses potential medical use in opioid withdrawal

“But the compounds in kratom aren’t particularly potent opioids like prescription opioids, morphine or fentanyl. So we started investigating its traditional use from Malaysia where people used it as an opium replacement or to wean themselves off of opium–a different type of methadone or Suboxone (buprenorphine/naloxone) maintenance therapy,” says McCurdy.

​(McCurdy was able to secure some funding from an already existing NIH Center grant at Ole Miss from the National Institute for General Medical Sciences, the Center for Research Excellence in Natural Products Neuroscience to conduct extensive scientific research into Kratom)

McCurdy had been well-versed in the previous work on kratom in animal models, particularly that by Hirosuto Takayama and colleagues at Chiba University in Japan. Takayama who was the first to show that mitragynine and 7-hydroxymitragynine could bind to opioid receptors in guinea pigs and mice. Together with Jessica Adkins, McCurdy and Boyer’s published a 2011 review on kratom alkaloids in Current Topics in Medicinal Chemistry, considered a definitive overview of the science up through the beginning of the decade … They repeatedly dosed mice with morphine to get them addicted. Then they stopped giving morphine and gave mice either plain food or food with freeze-dried extracts of kratom tea. The kratom tea extract almost completely blocked the morphine withdrawal symptoms.

Original Article:
Top Kratom Researcher Discusses Potential Medical Use In Opioid Withdrawal
Artwork Fair Use: Addictionblog.com

Anxiety, meet magic

The whole fungus: fine

Tripping with Buddha

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