Magic mushrooms do the opposite of anti-depressants, but that may be why they work
What’s striking is the alleviation of depression occurs from emotional receptivity being enhanced – the opposite of SSRI antidepressants.
“It has been proposed that decreased amygdala responsiveness to negative emotional stimuli under SSRIs is a key component of their therapeutic action,” the researchers explain, “but the present study’s findings suggest that this model does not extend to the therapeutic action of psilocybin for [treatment-resistant depression]. The researchers don’t know for sure why that is, but after the experiment the patients reported “a greater willingness to accept all emotions post-treatment (including negative ones)” (original emphasis), whereas they felt their previous depression treatments worked to “reinforce emotional avoidance and disconnection.”
Original Article (Science Alert):
Magic Mushrooms Do The Opposite of Anti-Depressants, But That May Be Why They Work
Artwork Fair Use: Silvaticus