Science

[National Institutes of Health 2021 grant]… Structure and function of G protein-coupled receptors [GPCR] heteromeric complexes in brain

Grant Project 5R01MH084894-12: Our published data and the preliminary data presented here support our working hypothesis that inter-family GPCR heteromerization affects structure, sub-cellular localization and function of both 5-HT2AR and mGluR2 in living mammalian cells.

Our data are also consonant with the hypothesis that a single dose of hallucinogenic 5-HT2AR agonists induces fast-acting and long-lasting effects on remission of behavioral states associated with depression, and that these therapeutic-related phenotypes require expression of 5-HT2AR and mGluR2 as a GPCR heteromer in the frontal cortex of mice… [Virginia Commonwealth University].

Original Article (NIH Report):
Structure and function of GPCR heteromeric complexes in brain
Artwork Fair Use: Public Domain

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