Salvia divinorum [&] analgesic & anti-inflammatory action
…the minutes-long hallucinogenic and dissociative effects of recreational S. divinorum in humans have been described in detail.
Salvia divinorum… inhibited contractions of the mouse colon, stomach, and ileum in vitro; prolonged colonic propulsion; and slowed upper GI transit in vivo by activating KOR, CB1, and interestingly by activating cannabinoid type 2 receptors (CB2). In our laboratory, we coadministrated S. divinorum hydroponic extract (containing both salvinorin A and B) and anandamide (cannabinoid agonist), and we found a synergic effect at low doses of both compounds (10 and 30 µg/kg, respectively). This coadministration induced an analgesic effect in two of the main behavioral responses of this test, licking and escape, involved in the spinal and supraspinal nociceptive process.
Original Article (Dove Press):
Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action
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