Understanding the 5 M’s [5 S’s and 5 C’s] of LSD and Ergot

5 S’s
[safety]

*Safety 1: the ergot fungus pictured above (Claviceps purpurea, Claviceps paspali, Claviceps 
spp); of various plants shown here is not LSD, but has an ethnobotanically and historically-significant relationship with LSD. Ergot alkaloids are also found in many climbing plants (Convolvulacae), not pictured above. (Rastsch 2005).

*Safety 2: The ergot alkaloids can be divided into two groups that exhibit stark pharmacological differences. (Ratsch 2005).

*Safety 3: One group is composed of alkaloids that are highly toxic and cause gangrenous ergotis, while the other groups consists of psychoactive alkaloids. Both types may be present in the same plant (Hoffman 1964*).

*Safety 4:  Consuming ergot may lead to “ergot poisoning”. 

*Safety 5: Self-experimentation is absolutely is not recommended. (Ratsch 2005).

5 M’s
[measures]

[ Regarding LSD ] : Understanding the 5 M’s when trying to have a certain ‘type’ of psychedelic experience is important. Microdose, mini-dose, museum dose, moderate dose, and mega dose. Each will have a different impact, often scaling in intensity as the amount increases.

1. Microdose is sub-perceptual [6 and 20 micrograms [of LSD] according to Thirdwave], meaning you cannot detect any changes in your day to day. But, over the first couple weeks, things start to gradually improve. Like fish oil, or medicinal mushrooms, or eating healthier, this level is more like a ‘supplement’ to support well-being.

2. Mini-dose is slightly perceptible. [inferred as 20-50micrograms] Enhanced sense of touch and smell, more willing to play and be goofy, better access to conceptual thinking and creativity, deeper reflection if combined w/ meditation. Definitely noticed you took a little…

3. Museum dose is 50-75 micrograms of L, that significantly enhances appreciation of artistic expression, as well as all senses. If done in the ‘wild’ (i.e. public), smart to have prior experience with psychedelics…

4. Moderate dose is 100-200 micrograms, often with slight visuals and a sense of living in a world of magic. Best if done alone with an eye shade and music and/or outdoors with a small group of close friends…

5. Mega dose is 250+ micrograms… some overwhelming beautiful, others quite harrowing. Best reserved for those experienced with altered states as things get a bit crazy in the mind at high levels.

5 C’s
[contexts]

 
Context 1. LSD is [described as] a psychopharmaca, a “remedy for the soul” (Albert Hoffman), whose entheogenic effects are very well known. (Hoffman 1979*).  

Context 2. [Conversely, ergotism caused by ergot poisoning], consists of a mortifying gangrene of a limb… such pain and such heat arise with this disease that it is tantamount to a real burn. (Ratsch 2005, In Bauer 1973, 22). 

Context 3. 
The first scientific report on ergot as a uterotonic agent appeared in 1808.  Ergot, or secale cornutum, is an ancient agent for inducing labor and still finds today use in homeopathy, Since the middle ages, midwives have used ergot to induce labor. (Ratsch 2005).

Context 4. Research has shown that the prophylactic use of uterotonic agents [in this case prophylactic ergot alkaloids] in the third stage of labour reduces both postpartum blood loss and postpartum haemorrhage.  “Use of ergot alkaloids in the third stage of labour decreased mean blood loss (mean difference (MD) ‐80.52 mL, 95% confidence interval (CI) ‐96.39 to ‐64.65 mL; women = 2718; studies = 3; moderate‐quality evidence); decreased PPH of at least 500 mL (average risk ratio (RR) 0.52, 95% CI 0.28 to 0.94; women = 3708; studies = 5; I2 = 83%; low‐quality evidence); increased maternal haemoglobin concentration (g/dL) at 24 to 48 hours postpartum (MD 0.50 g/dL, 95% CI 0.38 to 0.62; women = 1429; studies = 1; moderate‐quality evidence); and decreased the use of therapeutic uterotonics (average RR 0.37, 95% CI 0.15 to 0.90; women = 2698; studies = 3; I2 = 89%; low‐quality evidence). There were no clear differences between groups in severe PPH of at least 1000 mL (average RR 0.32, 95% CI 0.04 to 2.59; women = 1718; studies = 2; I2 = 74%; very low‐quality evidence). The risk of retained placenta or manual removal of the placenta, or both, were inconsistent with high heterogeneity. Ergot alkaloids increased the risk of elevated blood pressure (average RR 2.60, 95% CI 1.03 to 6.57: women = 2559; studies = 3; low‐quality evidence) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78: women = 1429; studies = 1; moderate‐quality evidence) but there were no differences between groups in vomiting, nausea, headache or eclamptic fit.”1

Context 5. Again, LSD and ergot  should not be confused with each other, as their safety profile, effects, and overall context traverse a wide-range of applicably as well as safety concerns.  A common recommendation : seek professional guidance.

Original Article:
 Understanding the 5 M’s and Paul Austin and Chochrane Library
Artwork Fair Use: Ratsch, Christian (2005)

The 15-ounce pound revisited

The whole fungus : good

LSD, Reconsidered for Therapy

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