Biography/Memoir

…potency of psychedelics in the brain

[From his two-story lab in University of North Carolina, Chapel Hill School of Medicine, Bryan Roth’s experiments are underway to remove the powerful hallucinogenic effects from psychedelic drugs… idea prompted a $27 million grant from the Defense Advanced Research Projects Agency (DARPA), a secretive research organization within the U.S. military… everyone from the Department of Defense to venture capitalists are monitoring his work… is expected to last for four years [as reported in June 2021], depending on the success of the experiments.]

…[the] team from the University of North Carolina at Chapel Hill School of Medicine has investigated the contribution that our genes may play in affecting our brains’ reactions to psychedelics…“Clinical studies have found a wide variety of responses to psychedelic drugs, with some patients seeing huge benefits after treatment and some seeing no benefits at all. Our study suggests that genes matter in determining how sensitive we are to the effects of psychedelics,” said Schmitz… the differences seen at a cellular level might not be a direct predictor of response at the level of the whole brain in clinical trials. Our understanding of how psychedelics mediate their therapeutic effects is still unclear – which is hardly unique – and some researchers have suggested that the 5-HT2A receptor – while being key to psychedelics’ hallucinatory effects – might not even be involved in these drugs’ antidepressant effects.

Original Article (Technology Networks):
Our DNA could affect the potency of psychedelics in the brain
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