Those who reported taking a higher dose, and experiencing more insight and mystical-type effects, tended to report greater reduction in drug consumption. Johnson and his colleagues found that most of the participants reported using LSD or psilocybin to induce the psychedelic experience in question. Approximately 79% of participants met the DSM-5 criteria for severe substance…
Basically, there is evidence that pills we are prescribed for other purposes can have profound effects on our relationships and romantic neurochemistry, only in ways that aren’t widely appreciated or fully understood. This is because Western medicine tends to measure the effects of drugs on individuals and their personal symptoms, without paying as much attention to…
Study on more than 40,000 people on opioid addiction treatment finds significant reduction in OD and health complications in patients on buprenorphine & methadone. Other behavioral or residential care, detox, naltrexone had same outcome as no treatment at all. -Dana Larsen Our finding that MOUD (medication for opioid use disorder) treatment with naltrexone was not…
Kratom was primarily taken orally in doses of 1−3 g (49 %), with daily use (59 %) being most common. Kratom was used for pain (91 %), anxiety (67 %), and depression (65 %), with high ratings of effectiveness. 1,144 (41 %) used kratom to stop or reduce prescription or illicit opioid use, citing decreased…
A new study in the journal Psychopharmacology suggests that drinking ayahuasca generates lasting improvements in mindfulness and cognitive flexibility, which may explain its therapeutic properties. Based on these apparent lasting increases in both mindfulness and cognitive flexibility, the study authors state that the ayahuasca afterglow period “could be therapeutically significant because a loosening of ‘cognitive grip’ may…
A pilot study involving 20 patients who’d previously not responded to up to 12 different antidepressants found they were significantly more likely to improve with ‘laughing gas’ treatment than those given a placebo gas. The benefits lasted several days. Now researchers have discovered that nitrous oxide also acts on glutamate, but in a slightly different…
“Our results show that people who take psychedelics ‘in the wild’ report positive experiences very similar to those observed in controlled laboratory studies,” said lead author Matthias Forstmann. By surveying 1,242 UK and US festivalgoers over a four-year period, the researchers were able to characterise the psychological effects of the “afterglow” often documented in laboratory-based…
Only cigarettes are deadlier than alcohol. The research shows that in 2017, alcohol proved to be even more deadly than illicit drugs, including opioids. That year there were about 70,000 drug overdose deaths — about 2,300 fewer than those involving alcohol Death certificates spanning 2017 indicate nearly 73,000 people died in the U.S because of…
HPPD is incredibly rare… In the 1960’s and the 1970’s, an estimate surfaced to show 1 in 20 people with hallucinogenic experiences had intermittent cases of HPPD. Fast forward to the 1990’s, and it was believed to be 1 in 50,000 regular users have chronic HPPD… Countless anecdotes from HPPD… sufferers vouch for the effects…
There have been several FDA-approved medications with 5HT2B receptor activation withdrawn from the US market due to the risk of VHD with heart valve thickening and murmurs: Fen-Phen (fenfluramine/phentermine) and Redux (dexfenfluramine) in 1997 and Permax (pergolide) in 2007. Roughly 25% of patients taking these medications daily developed new onset VHD according to incidence statistics…
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