There have been several FDA-approved medications with 5HT2B receptor activation withdrawn from the US market due to the risk of VHD with heart valve thickening and murmurs: Fen-Phen (fenfluramine/phentermine) and Redux (dexfenfluramine) in 1997 and Permax (pergolide) in 2007. Roughly 25% of patients taking these medications daily developed new onset VHD according to incidence statistics…
“I compare taking LSD to being a good rider of a powerful horse,” says [Amanda] Feilding. “In the right, carefully controlled, setting and with the right intention, you could use the psychedelic to achieve whatever you want. [On micro-dosing] “My current hypothesis is that it basically changes your brain in the same way as a…
Mushroom expert Paul Stamets cautions that there can be a difference… between batches of the same species. Despite these variables, some rough calculations can be done that may provide some insight for microdosing dried mushrooms. How does 0.5 – 2.0 mg (0.0005 – 0.002 g) of psilocybin translate into a dose of dried psilocybin mushroom…
In many cases, the legal cannabis industry has used alcohol and tobacco as their model for a legal market. In turn, it’s tempting for the coming psychedelic industry to use cannabis as theirs, but this approach might be just as flawed as the Controlled Substances Act which places fundamentally different substances in the same category……
But why is decriminalization, specifically, important to this movement? Why not aim for other approaches, like legalization (where psychedelics are regulated like alcohol), or medicalization (where psychedelic therapy is the only legal option)? This first wave of acceptance towards psychotropic plants is now starting to include psychedelics, with successful psychedelic decriminalization efforts in both Denver…
“We’re talking about several thousands… that are suffering every day that treatment continues to be withheld from them,” Bruce Tobin [of the University of Toronto launched the Centre for Psychedelic Studies] said. “Treatment delayed is treatment denied.” [Dana Larsen], the longtime cannabis rights advocate from Vancouver is known for protesting against drug laws… has now…
Samples testing positive for fentanyl also tested positive for meth rose almost 14-fold… and by more than sixfold for cocaine and heroin. Similarly, the percentage [of] tests coming back positive for the highly potent — and sometimes fatal — opioid fentanyl have more than quadrupled since 2013, the study found. Original Article (UPI):Meth use up…
The motivation behind these group dosage experiments is primarily about exploring ways to streamline the treatment process… [COMPASS claims] scheduling more than one patient at a time offers the potential for accelerating the pace of clinical trials. However, it is worth noting, this particular study was conducted with psychologically healthy individuals, and not subjects suffering…
Private investment in the space needs to be coupled with research into their social impact… Liana Gillooly, a development officer at MAPS, a non-profit investigating the therapeutic uses of psychedelics, with an early focus on MDMA as a potential treatment for PTSD. But Gillooly said that funding needs to be set aside for “safe contexts”…
Based on what is known about the cannabinoids in cannabis plants… …it is plausible that there is synergy going on between the multiple active and inactive compounds in these mushrooms. Magic mushrooms contain more than just psilocybin … seemingly minor differences in the chemical structures can have dramatic effects on the cellular and clinical pharmacology of…
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