…production [of psilocybin] in bacteria [such as e-coli] comes with a wide range of concerns [some of which] can be addressed by using yeast instead. In yeast, the scientists prove that psilocybin can be produced de novo, which means that you can produce the molecule by simply growing the yeast with sugar and other nutrients,…
Studies have shown that it may alleviate pain and aid in reducing alcohol and opioid dependence. The mechanisms for these actions are thought to be mediated through the mu, delta, and kappa opioid receptors… also has an affinity for several other receptor types that may be involved in its effects. Original Article (Psychedelic Review):Kratom compound…
Psilocybin-[containing mushrooms work] along a similar pathway to serotonin, which results in your brain producing a similar effect to serotonin. The main effect is to stimulate a serotonin receptor called “5-HT2A” which is found in the prefrontal cortex. Stimulating this receptor results in two key results. The first being triggering the production of “Brain Derived…
This finding was published Monday, [April 13, 2020] in Proceedings of the National Academy of Sciences … If the magic mushrooms demonstrate anything, it’s that the brain can learn to use its fixed hardware in very different ways, if the right ingredients are involved. The trick is figuring out what tools the brain needs to run different types…
“What is truly groundbreaking is FDA’s rightful acknowledgement that MDD (Major Depressive Disorder], not just the much smaller treatment-resistant depression population, represents an unmet medical need and that the available data suggest that psilocybin may offer a substantial clinical improvement over existing therapies.” -Dr. Charles Raison, MD Compass Pathways, a pharmaceutical research firm, received the…
Barrett and his team also observed a decrease in amygdala response to emotional information for one week after administration, though this to returned to baseline in the next test, one month later. It’s a small sample, and relied on a lot of self-reporting, but respondents claimed emotional distress was reduced in the week following [synthetic]…
Scientists are suing the Drug Enforcement Administration over its alleged use of a “secret law” to delay the expansion of marijuana research. They want access to an internal Justice Department memo that could reveal how the federal government is relying on an interpretation of international treaties to impede studies … The new revised rule … shifting jurisdiction…
Those who reported taking a higher dose, and experiencing more insight and mystical-type effects, tended to report greater reduction in drug consumption. Johnson and his colleagues found that most of the participants reported using LSD or psilocybin to induce the psychedelic experience in question. Approximately 79% of participants met the DSM-5 criteria for severe substance…
Basically, there is evidence that pills we are prescribed for other purposes can have profound effects on our relationships and romantic neurochemistry, only in ways that aren’t widely appreciated or fully understood. This is because Western medicine tends to measure the effects of drugs on individuals and their personal symptoms, without paying as much attention to…
Study on more than 40,000 people on opioid addiction treatment finds significant reduction in OD and health complications in patients on buprenorphine & methadone. Other behavioral or residential care, detox, naltrexone had same outcome as no treatment at all. -Dana Larsen Our finding that MOUD (medication for opioid use disorder) treatment with naltrexone was not…
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