Ibogaine (12-methoxyibogamine) is the main alkaloid of at least 12 alkaloids found in the Tabernanthe iboga plant. [One of the alkaloids, mentioned above] seems to activate the glial cell line-derived neurotrophic factor (GDNF) pathway in the ventral tegmental area of the brain, increasing its expression. Previous studies have found that the GDNF pathway plays a unique role in…
*The power of psychedelics is that they can reveal, in the span of a few hours, depths of awe and understanding that can otherwise elude us for a lifetime. —Sam Harris *About 20 million Americans have done mushrooms. And the Global Drug Survey says mushrooms carry the lowest physical risk of any recreational drug. “I’m…
One of the puzzles of climate science is the persistence of the Holocene Optimum – ten thousand years of anomalously stable climate that has allowed civilization to flourish. Science, as far as I can tell, attributes this basically to good luck. I have encountered among indigenous people a completely different explanation… …that the rituals performed…
“Once I tried to explain heaven to a young woman,” she said, smiling, as she poured Shultes a cup of tea. “I said it was as beautiful place, a place where there are no tears. She asked me whether I had been there. I said no. I explained that only the dead know heaven. Then…
*What’s striking is the alleviation of depression occurs from emotional receptivity being enhanced – the opposite of SSRI antidepressants. Despite the recent renaissance of psychedelic science, psilocybin still languishes on the DEA’s “Schedule I” – a kind of political prison for drugs which, according to the DEA, have “no therapeutic value” and a “high potential…
” I agree with everything Trevor said but there is unfortunately a complication which is to a surprising degree you can’t always trust what scientists say … This is definitely an area where we need informed, intelligent, lay people also to be perceived to have a very legitimate voice in the debate.” -Terence Kealey : Senior Fellow at Cato…
Fentanyl-laced or “particularly pure,” fentanyl, or furanyl fentanyl [are the three substances apparently causing the overdoses, according to interviews conducted by the Register Guard]. [Furanyl fentanyl] was… made illegal in November 2016. Similar to heroin and morphine, but is a hundred times more potent, produces a longer-lasting high and is more difficult to treat if a person overdoses, the…
5 S’s[safety] *Safety 1: the ergot fungus pictured above (Claviceps purpurea, Claviceps paspali, Claviceps spp); of various plants shown here is not LSD, but has an ethnobotanically and historically-significant relationship with LSD. Ergot alkaloids are also found in many climbing plants (Convolvulacae), not pictured above. (Rastsch 2005). *Safety 2: The ergot alkaloids can be divided into two…
Bernard was finally granted parole after being sentenced to 13 years for allegedly possessing two joints of marijuana. …this grave injustice directly from the man whose case drew national attention as an example of extremely harsh drug sentences in the United States, and how an entire family is tragically affected when a parent is sent…
It is known that many psychotropic mushrooms (above all, Psilocybe and Panaeo/us genera) live in dung of certain quadrupeds and in particular bovines, cervides and equines. This specific ecological phenomenom cannot but have been taken into account with regard to the sacramental use of psychotropic mushrooms, leading to the creation of mystico-religious relations between the mushroom and…
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