Researchers at Imperial College London [report]… Use of cannabis together with psychedelics was “associated with higher scores of mystical-type experience, ego-dissolution and visual alterations,” the study, published last week in the journal Psychopharmacology, states. And in general, the more marijuana a person said they used, the more intense the psychedelic effect… there was a unique…
…[ie] deuterated psilocybin analog has a duration of effect that is half is long as psilocybin, and a duration onset that is twice as fast. …[research pipeline seeking & developing] drugs with less variability [with goals such as] a faster onset time and better brain penetration that maintain the therapeutic properties of psilocybin and deliver…
…a 35-percent response rate and a 5-percent SAE rate means for every seven patients positively responding to the treatment, one person will experience serious negative outcomes… these serious adverse events included suicidal ideation and suicidal behavior. Five patients (6.3 percent) in the 25-mg group and six patients (8 percent) in the 10-mg group experienced at…
With… propriety technology… stable formulations of both psilocin and psilocybin from magic mushrooms. …drug development efforts are focused exclusively on extracting, purifying, and standardizing natural psychedelic compounds. Original Article (Psychedelic Spotlight):FDA approves first clinical trial using naturally sourced psychedelicsArtwork Fair Use: Perdula
…the variability of compounds in magic mushrooms… environmental variables such as light and the type of growing medium influence the presence and amount of certain compounds… in the mushroom fruiting bodies… …isolated and tested for multiple compounds of interest in the mushroom including the tryptamine alkaloids: baeocystin, norbaeocystin, norpsilocin, aeruginascin, 4-HO-TMT, 4-hydroxytryptamine. The beta-carbolines: harmine, harmane, norharmane, harmol. Original Article (Psychedelic Science…
…the minutes-long hallucinogenic and dissociative effects of recreational S. divinorum in humans have been described in detail. Salvia divinorum… inhibited contractions of the mouse colon, stomach, and ileum in vitro; prolonged colonic propulsion; and slowed upper GI transit in vivo by activating KOR, CB1, and interestingly by activating cannabinoid type 2 receptors (CB2). In our laboratory, we…
“The findings suggest that lifetime classic psychedelic use is associated with lower odds of having had heart disease or diabetes in the past year,” lead study author and Oxford sociologist Otto Simonsson, [said]. A team of scientists identified the unexpected trend after poring over ten years’ worth of data from the National Survey on Drug…
For a regulating body like the FDA, researchers aiming to put a psychedelic drug and treatment through the clinical research pipeline only need to prove two things: that the drug (and its associated protocols) are safe, and that they work successfully at treating the indication they’re after. While multiple psychedelic substances are currently undergoing dozens…
Across a wide range of body weights (49kg [approx. 108lbs] to 113 kg [approx. 249lbs]) the present results showed no evidence that body weight affected subjective effects of psilocybin. In the 20 mg/70 kg and 30 mg/70 kg weight-adjusted groups, and in the fixed dose group, no significant associations were found between subjective effects and demographic variables including body weight…
To link DMN [Default Mode Network] disintegration to a mental state as particular as ego-dissolution is to conveniently ignore years of non-psychedelic research findings. Returning to psychedelics, to claim that the DMN is the neural seat of the ego — and that its disintegration represents ego loss — is an ambitious reverse inference. To prove…
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