Science

Posttreatment brain effects of psilocybin in patients with treatment-resistant depression

November 28, 2017By 0 comment

Changes in resting-state brain blood flow and functional connectivity following the use of psilocybin in patients with treatment-resistant depression have been documented for the first time, according to the results of a recent open-label UK study published in Scientific Reports. Investigators collected functional magnetic resonance imaging (fMRI) data from patients with treatment-resistant depression in order…

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Science

Kratom LD-50 Stats

November 21, 2017By 0 comment

[It appears], you’d need to eat a whole tree in one sitting to die of kratom. Both alkaloid extract (ED50=194.4 mg/kg) and mitragynine (ED50= 21.96 mg/kg) significantly and dose-dependently showed analgesic effect compared to morphine (ED50=3.69 mg/kg). In addition, based on the acute toxicity study the LD50 for alkaloid extract and mitragynine was estimated 591.6…

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What LSD tells us about human nature

November 3, 2017By 0 comment

Healthy volunteers were injected with LSD while lying in an MRI scanner, and subjected to several other neuroimaging methods at the same time. This amounted to an arsenal of measurement that previous decades of psychedelic researchers could only dream of. ​Humans have gathered, cultivated, distilled, and manufactured all kinds of drugs for thousands of years.…

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Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

October 13, 2017By 0 comment

This study was approved by the National Research Ethics Service (NRES) committee London – West London and was conducted in accordance with the revised declaration of Helsinki (2000), the International Committee on Harmonisation Good Clinical Practice (GCP) guidelines and National Health Service (NHS) Research Governance Framework. Imperial College London sponsored the research which was conducted…

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Mind-altering therapy : psilocybin therapy to combat depression

October 4, 2017By 0 comment

Spokesperson Tracey Cheung told us natural psilocybin extraction is difficult and expensive to produce to cGMP standards. “Given the urgent unmet need, Compass has chosen to synthesize psilocybin to expedite research and regulatory approval to bring this treatment to patients without unecessary delays,” she said. “We plan to extend research into extracts at a later…

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Legal MDMA could soon be a thing

September 24, 2017By 0 comment

Don’t go thinking that ecstasy bought on the streets is good for you though, laboratory studies have shown that only pure MDMA has been proven sufficiently safe for human consumption when taken a limited number of times in moderate doses. ​ After extensive research, the U.S. Food and Drug Administration (FDA) has now confirmed it’s…

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Psychedelics vs. inflammation

September 22, 2017By 0 comment

One thing you probably don’t think of… [psychedelics] as is an anti-inflammatory medicine. Like aspirin or ibuprofen … It turns out, there may be reason to. ​ The data is unequivocal if you’re a mouse, because the studies have already been conducted. And Dr. Charles Nichols is working on extending this research into humans. But…

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Long-term follow-up of psilocybin-facilitated smoking cessation

September 11, 2017By 0 comment

A recent open-label pilot study (N = 15) found that two to three moderate to high doses (20 and 30 mg/70 kg) of the serotonin 2A receptor agonist, psilocybin, in combination with cognitive behavioral therapy (CBT) for smoking cessation, resulted in substantially higher 6-month smoking abstinence rates than are typically observed with other medications or…

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