To link DMN [Default Mode Network] disintegration to a mental state as particular as ego-dissolution is to conveniently ignore years of non-psychedelic research findings. Returning to psychedelics, to claim that the DMN is the neural seat of the ego — and that its disintegration represents ego loss — is an ambitious reverse inference. To prove…
Grant Project 5R01MH084894-12: Our published data and the preliminary data presented here support our working hypothesis that inter-family GPCR heteromerization affects structure, sub-cellular localization and function of both 5-HT2AR and mGluR2 in living mammalian cells. Our data are also consonant with the hypothesis that a single dose of hallucinogenic 5-HT2AR agonists induces fast-acting and long-lasting…
Funding from the National Institute of Health [NIH], which tends to award larger grants than philanthropists, allows researchers to delve more into the details, Johnson says. Grant Project Number 1K23MH122777-01A1: We hypothesize that psilocybin will result in increased (i.e. normalized) intra-DMN functional connectivity in OCD, and that this will correlate with any clinical change (Aim 1). Baseline…
“The funding side of the government has been the last to the party for a long time,” says Matthew Johnson, who studies psychedelics at Johns Hopkins University. Grant Project Number 1U01DA052174-01A1: We hypothesize that psilocybin (compared to niacin) will cause increased biologically-confirmed 7-day point-prevalence abstinence at 12-month follow-up. Based on pilot data, we will test cognitive/psychological mediators…
…to prevent the degradation of alkaloids, the most suitable conditions were to dry the mushrooms whole and store in the dark at room temperature. Regardless of storage, rapid degradation of all tryptamines was observed in powder form. In the first month [re: powdered mushrooms] the greatest decrease occurred and through the second month the overall…
“The funding side of the government has been the last to the party for a long time,” says Matthew Johnson, who studies psychedelics at Johns Hopkins University. Grant Project Number 1U01DA052174-01A1: We hypothesize that psilocybin (compared to niacin) will cause increased biologically-confirmed 7-day point-prevalence abstinence at 12-month follow-up. Based on pilot data, we will test cognitive/psychological mediators…
To determine the amount of psilocybin and psilocin in each submission, the scientists… used a technology called High-Performance Liquid Chromatography (HPLC). …much like what happened with cannabis and THC, there’s been laser-focus on one compound in magic mushrooms – psilocybin. While it’s certainly important to understand the compounds that produce such a strong psychoactive effect, it’s also…
Significant growth was also observed at concentrations as low as 100 picomolar. These concentrations are well below measured levels in humans required to achieve psychedelic breakthrough. This initial data set is from… in vitro experiments designed to provide information on the dose and duration of infusion needed to achieve maximal cortical neurite outgrowth as well as…
A 2020 survey of 2,798 American Kratom users by Johns Hopkins Medicine found that less than 3% of respondents met the criteria for moderate or severe kratom use disorder… A 2019 study in Preventative Medicine estimated that “the risk of overdose death is >1000 times greater for opioids than for kratom.” While most morphine-like opiate overdoses are…
…the most interesting finding in this study is that Kratom by itself can suppress and kill cancer cells to a certain extent. [University Sains Malaysia study now on Pubmed]… since Big Pharma makes countless billions of dollars on cancer drugs/treatments, it is incredibly unlikely that any company would fund the research necessary to thoroughly ascertain…
Recent Comments