In contrast to the primary hypothesis, psychedelics had no long-lasting effects on the ADE (alcohol deprivation effect) in male and female rats… …when administered in a high dosage regime that is comparable to the one used in clinical studies… Original Article (Nature):Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapseArtwork…
“…I want nothing to do with those kinds of folks who want to decriminalize psychedelics,” he says [a 32-year-old former Uber employee and co-founder]. …[he is part of] one of many companies trying to repurpose hallucinogenic molecules as the next blockbuster drug… has acquired the exclusive rights to eight clinical trials that are exploring the…
“Our results show that people who take psychedelics ‘in the wild’ report positive experiences very similar to those observed in controlled laboratory studies,” said lead author Matthias Forstmann. By surveying 1,242 UK and US festivalgoers over a four-year period, the researchers were able to characterise the psychological effects of the “afterglow” often documented in laboratory-based…
“I compare taking LSD to being a good rider of a powerful horse,” says [Amanda] Feilding. “In the right, carefully controlled, setting and with the right intention, you could use the psychedelic to achieve whatever you want. [On micro-dosing] “My current hypothesis is that it basically changes your brain in the same way as a…
Single “microdoses” of LSD produced orderly dose-related subjective effects in healthy volunteers. Numerous anecdotal reports suggest that repeated use of very low doses of lysergic acid diethylamide (LSD), known as “microdosing,” improves mood and cognitive function. These effects are consistent both with the known actions of LSD on serotonin receptors, and with limited evidence that…
Psychedelic experiences may not be so reliably enlightening or helpful (or legal) when done recreationally, especially at a young age. LSD and mushrooms combined with prayer and intention [have] helped put… [some individuals] on a path of healthy eating and yoga. [Others] warn about the risk of spiritual bypassing—using spiritual practices as a way to…
This present research focuses on the effect of LSD on alcohol intake in a two-bottle choice drinking paradigm in C57BL/6J mice, an inbred alcohol-preferring strain (Melo et al., 1996). In the group treated with 50 μg/kg LSD, mean daily ethanol consumption was 13.62 ± 3.02 g/kg/day compared to 16.60 ± 3.52 g/kg/day (mean ± SD)…
5 S’s[safety] *Safety 1: the ergot fungus pictured above (Claviceps purpurea, Claviceps paspali, Claviceps spp); of various plants shown here is not LSD, but has an ethnobotanically and historically-significant relationship with LSD. Ergot alkaloids are also found in many climbing plants (Convolvulacae), not pictured above. (Rastsch 2005). *Safety 2: The ergot alkaloids can be divided into two…
From a physiological perspective, however, LSD is known to be non-toxic and medically safe when taken at standard dosages (50–200 μg). The scientific literature, along with recent media reports, have unfortunately implicated “LSD toxicity” in five cases of sudden death. On close examination, however, two of these fatalities were associated with ingestion of massive overdoses,…
1) Peter (74) : What advice would you give young people looking to experiment with LSD? … 2) Holger (64) : If you could impart some wisdom about LSD on your 17-year-old self, what would it be? … 3) Adam (54) : What would you tell a young person who’s considering experimenting with psychedelic drugs?…
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