The trial will begin in the first quarter of 2018 and is planned to include clinical sites in Czech Republic, Finland, Germany, the Netherlands, Norway, Portugal, Spain and the UK. COMPASS Pathways is a healthcare company, founded in 2015 to accelerate patient access to evidence-based innovation in mental health. We are developing psilocybin therapy through…
A new study from researchers at the University of Rochester Medical Center and the University of British Columbia compiling 57 years of research into the drug and its effects on mental health found the substance “has harm reduction potential for substance users who want to quit opioids.” … The study also found that it can…
We cannot know the future, but there are a number of reasons to believe that psychedelic medicine really can break out of its ghetto and into the mainstream … What must not be allowed to happen is for these promising and much-needed drugs to fail for anything other than the purest of scientific reasons. More…
Thomas and his two colleagues, Benjamin Malcolm and Dan Lastra, came to this conclusion after reviewing seven clinical trials on psilocybin-assisted therapy. These previous studies were published over the past decade and examined cancer-related anxiety, obsessive-compulsive disorder, depressive disorders, and addiction. “This therapy has also demonstrated large effect sizes for improving symptoms on validated psychiatric…
*Peace Monument in Washington D.C. Could Kratom be the CBD of the opiate world? … Ironically, the greatest danger of Kratom these days is from fake products contaminated with substances approved by the FDA. In rats, there was no observed toxicity following single, huge oral doses up to 806 mg/kg of [mitragyine]. (CBD is also…
“…kratom… has not been linked to any known deaths, and the plant has little potential for abuse and dependence – as low or lower than such widely used (and federally unscheduled substances) as “nutmeg, hops, St. John’s Wort, chamomile, guarana, and kola nut.” -Dr. Henningfield* Dr. Henningfield previously served as chief of the Clinical Pharmacology…
Changes in resting-state brain blood flow and functional connectivity following the use of psilocybin in patients with treatment-resistant depression have been documented for the first time, according to the results of a recent open-label UK study published in Scientific Reports. Investigators collected functional magnetic resonance imaging (fMRI) data from patients with treatment-resistant depression in order…
[It appears], you’d need to eat a whole tree in one sitting to die of kratom. Both alkaloid extract (ED50=194.4 mg/kg) and mitragynine (ED50= 21.96 mg/kg) significantly and dose-dependently showed analgesic effect compared to morphine (ED50=3.69 mg/kg). In addition, based on the acute toxicity study the LD50 for alkaloid extract and mitragynine was estimated 591.6…
GRAPH : How each substance performs regarding the average (dashed line) of overall weighted scores. Substances above the dashed line (red) do more harm than the average value. Substances below the dashed line (pale pink) do less harm than average value. The shocking reality of the role alcohol plays in people’s lives has been revealed in a…
Healthy volunteers were injected with LSD while lying in an MRI scanner, and subjected to several other neuroimaging methods at the same time. This amounted to an arsenal of measurement that previous decades of psychedelic researchers could only dream of. Humans have gathered, cultivated, distilled, and manufactured all kinds of drugs for thousands of years.…
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