Changes in global and thalamic brain connectivity in LSD-induced… states of consciousness…
Despite its powerful effects on consciousness, human research on LSD neurobiology stalled in the late 1960s because of a narrow focus on the experiential effects of hallucinogenic drugs, combined with a lack of understanding of its effects on molecular signaling mechanisms in the brain.
However, renewed interest in the potentially beneficial clinical effects of psychedelics (Carhart-Harris et al., 2016a; Gasser et al., 2014; Griffiths et al., 2016) warrants a better understanding of their underlying neuropharmacology. Nevertheless, major knowledge gaps remain regarding LSD’s neurobiology in humans as well as its time-dependent receptor neuropharmacology. To address this critical gap, the current study aims to comprehensively map time-dependent pharmacological effects of LSD on neural functional connectivity in healthy human adults and compare them to the spatial expression profile of genes coding for receptors interacting with LSD.
Original Article (eLifesciences):
Researchers explain how LSD changes perception
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