Psychology

Microdoses of LSD show antidepressant effects in placebo-controlled study

…researchers at the University of Chicago have discovered that low doses of lysergic acid diethylamide (LSD), a psychedelic drug, may have potential antidepressant effects in individuals showing mild to moderate depressive symptoms… the findings have been published in the journal Neuropsychopharmacology. “There has been a great deal of public interest in ‘microdosing,’ or the idea…

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Science

Effects of external stimulation on psychedelic state neurodynamics

Stronger external stimulation increases baseline entropy and reduces the drug effect. Results show that while brain entropy increases with LSD under all of the experimental conditions, it exhibits the largest changes when subjects have their eyes closed. Furthermore, brain entropy changes are consistently associated with subjective ratings of the psychedelic experience, but this relationship is…

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Politics

California campaign… psychedelics submits final version of proposed 2024 ballot measure

While adults would be allowed to legally grow, possess and use substances like psilocybin, LSD, MDMA, DMT, ibogaine and mescaline under the measure, they would need physician recommendations to purchase the psychedelics at regulated stores. Cultivation on private property of psychedelic plants and fungi would be legal provided it’s done out of public view and…

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Science

Psychedelics can relieve chronic pain, new survey suggests

A new study published in the European Journal of Pain last month [July 2023] found that both macro and micro doses of classic psychedelics — LSD, psilocybin, DMT, mescaline — led to better pain relief compared to conventional medication in volunteers surveyed. “Participants reported that full doses seem to achieve better perceived results in pain relief than…

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Science

UC Berkeley… psychedelics survey

The majority of American voters support policy reforms for psychedelics, the survey revealed… over half of voters (56%) polled support obtaining FDA approval for psychedelics by prescription. Almost half (49%) support removing criminal penalties for personal use and possession with support for spiritual and religious use polling at just over four out of ten (44%)……

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Science

Psychedelics reopen the social reward learning critical period

Juvenile mice find social experiences more rewarding than do adults. The discovery [is] that psychedelics can re-engage the social neural circuits for varying durations in adults… Gül Dölen, M.D., Ph.D., associate professor of neuroscience at the Johns Hopkins University School of Medicine.; …ibogaine, ketamine, LSD, MDMA, and psilocybin, can reopen the “critical periods” of brain…

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Science

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

…psychedelics spurred new growth in both baby and mature neurons. But the mind-bending substances were 1,000 times more efficient than Prozac at grabbing onto a key molecular hub, TrkB. With just a single dose, the drugs elevated mood in mice under chronic stress and reduced a previously-established fear. Psychedelics produce fast and persistent antidepressant effects…

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Medicine/Healing

Can psychedelics save a failing relationship?

…psychedelics, such as magic mushrooms, 2CB, LSD or MDMA.  Juan-Carlos had been violently abused by his father and… realised that it had led him to become absent, jealous and insistent that Sophie was unfaithful. Their marriage had been on the brink, but now — following further psychedelic therapy sessions and structured psychiatric integration – it has…

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Psychology

The three types of psychedelic high

The Ohio State University College of Social Work conducted a study where they asked 1,000 participants to report the types of high some psychedelics gave them. They experimented with the effects of LSD, psilocybin… mescaline, ayahuasca, and 5-MeO-DMT (a close relative of DMT)… the research yielded 3 distinct types of psychedelic highs. (High scoring) –…

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