Anthropology

Risks associated with combining Bufo Alvarius with ayahuasca

The fact that there is no Indigenous group that is known to combine these compounds orally – despite their widespread availability and the broad knowledge surrounding them throughout the Amazon – is a good indicator that caution should be used when combining them.

Pharmacological studies have shown that at least one harmalinic compound (THH-tetrahydroharmine), as well as some metabolites of the harmalines present in ayahuasca that also have MAOI properties, remain in the blood for up to 24 hours following ingestion.[9] To avoid interactions individuals should wait at least 24 hours, after ingesting ayahuasca before inhaling Bufo alvarius. In the case that Bufo alvarius is smoked first, the individual should wait at least one hour before ingesting ayahuasca and not inhale Bufo alvarius for at least 24 hours afterwards. This advice is speculative, and therefore caution should be exercised – since it is unknown how these compounds or their metabolites interact in the brain. Under no circumstances should 5-MeO-DMT be combined orally with ayahuasca and/or harmalines.

Original Article (ICEERS):
Risks associated with combining Bufo Alvarius with ayahuasca
Artwork Fair Use: RicciSpeziari

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